| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sidney | city | North Carolina | United States | 34.19 | -78.79 | 65 | |
| Sidney Crossroads | city | North Carolina | United States | 35.48 | -76.68 | 3 | |
| Sign Pine | city | North Carolina | United States | 36.31 | -76.62 | 29 | |
| Signal Hill Apartments | city | North Carolina | United States | 35.79 | -80.85 | 830 | |
| Siler City | city | North Carolina | United States | 35.72 | -79.46 | 830 | |
| Silk Hope | city | North Carolina | United States | 35.78 | -79.37 | 830 | |
| Siloam | city | North Carolina | United States | 36.29 | -80.56 | 862 | |
| Silver Bluff | city | North Carolina | United States | 35.48 | -82.88 | 2700 | |
| Silver City | city | North Carolina | United States | 35.00 | -79.23 | 213 | |
| Silver Hill | city | North Carolina | United States | 34.89 | -79.48 | 301 | |
| Silver Hill | city | North Carolina | United States | 35.17 | -76.85 | 22 | |
| Silver Hill | city | North Carolina | United States | 35.71 | -80.21 | 830 | |
| Silver Lake | city | North Carolina | United States | 34.15 | -77.91 | 22 | |
| Silver Lake Mobile Home Park | city | North Carolina | United States | 34.14 | -77.91 | 22 | |
| Silver Springs | city | North Carolina | United States | 35.10 | -79.47 | 341 | |
| Silver Springs | city | North Carolina | United States | 36.42 | -76.67 | 22 | |
| Silver Valley | city | North Carolina | United States | 35.73 | -80.10 | 830 | |
| Silverdale | city | North Carolina | United States | 34.77 | -77.18 | 26 | |
| Silverstone | city | North Carolina | United States | 35.20 | -80.72 | 830 | |
| Silverstone | city | North Carolina | United States | 36.29 | -81.75 | 3349 | |
| Silverton | city | North Carolina | United States | 35.82 | -78.79 | 400 | |
| Simmons Bay | city | North Carolina | United States | 34.13 | -78.63 | 39 | |
| Simmons Corner | city | North Carolina | United States | 35.09 | -77.22 | 45 | |
| Simpson | city | North Carolina | United States | 35.58 | -77.28 | 26 | |
| Sims | city | North Carolina | United States | 35.76 | -78.06 | 200 | |
| Singing Springs | city | North Carolina | United States | 35.13 | -80.80 | 830 | |
| Sioux | city | North Carolina | United States | 36.02 | -82.36 | 2591 | |
| Sivey Town | city | North Carolina | United States | 33.97 | -78.31 | 39 | |
| Six Forks | city | North Carolina | United States | 35.90 | -78.65 | 413 | |
| Six Forks | city | North Carolina | United States | 34.59 | -77.89 | 32 | |
| Six Forks | city | North Carolina | United States | 35.86 | -78.66 | 308 | |
| Six Forks Crossroads | city | North Carolina | United States | 35.86 | -78.48 | 278 | |
| Six Points | city | North Carolina | United States | 35.28 | -81.75 | 905 | |
| Sixth Siding | city | North Carolina | United States | 35.67 | -76.66 | 13 |