| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Shackleford | city | Missouri | United States | 39.11 | -93.30 | 830 | |
| Shackleford Crossing | city | Missouri | United States | 38.89 | -93.03 | 830 | |
| Shade | city | Missouri | United States | 36.18 | -89.77 | 259 | |
| Shady Dell | city | Missouri | United States | 36.96 | -89.82 | 308 | |
| Shady Dell | city | Missouri | United States | 36.77 | -90.44 | 396 | |
| Shady Grove | city | Missouri | United States | 37.86 | -92.28 | 898 | |
| Shady Grove | city | Missouri | United States | 36.97 | -93.14 | 1669 | |
| Shady Grove | city | Missouri | United States | 37.51 | -92.88 | 1669 | |
| Shafter | city | Missouri | United States | 39.98 | -93.28 | 830 | |
| Shamrock | city | Missouri | United States | 39.00 | -91.69 | 830 | |
| Shannondale | city | Missouri | United States | 39.36 | -92.85 | 830 | |
| Shannondale | city | Missouri | United States | 37.39 | -91.44 | 1105 | |
| Shantytown | city | Missouri | United States | 38.03 | -92.05 | 1099 | |
| Sharon | city | Missouri | United States | 39.30 | -93.13 | 830 | |
| Sharp | city | Missouri | United States | 36.60 | -92.21 | 898 | |
| Sharpsburg | city | Missouri | United States | 39.69 | -91.76 | 830 | |
| Shaver Ford | city | Missouri | United States | 39.52 | -91.69 | 830 | |
| Shaw | city | Missouri | United States | 38.61 | -90.25 | 830 | |
| Shaw | city | Missouri | United States | 38.97 | -92.20 | 875 | |
| Shawan | city | Missouri | United States | 36.96 | -89.78 | 305 | |
| Shawne | city | Missouri | United States | 37.12 | -91.26 | 898 | |
| Shawnee Mound | city | Missouri | United States | 38.53 | -93.76 | 948 | |
| Shawneetown | city | Missouri | United States | 37.55 | -89.65 | 830 | |
| Sheil | city | Missouri | United States | 39.63 | -91.60 | 830 | |
| Shelbina | city | Missouri | United States | 39.69 | -92.04 | 830 | |
| Shelby | city | Missouri | United States | 39.97 | -93.02 | 898 | |
| Shelby | city | Missouri | United States | 36.50 | -91.52 | 830 | |
| Shelbyville | city | Missouri | United States | 39.81 | -92.04 | 830 | |
| Sheldon | city | Missouri | United States | 37.66 | -94.29 | 902 | |
| Shell Knob | city | Missouri | United States | 36.63 | -93.63 | 1187 | |
| Shelton Ford | city | Missouri | United States | 37.35 | -90.48 | 830 | |
| Shepard (historical) | city | Missouri | United States | 37.70 | -90.89 | 1669 | |
| Shepherd of the Hills Estates | city | Missouri | United States | 36.69 | -93.12 | 830 | |
| Sheridan | city | Missouri | United States | 40.52 | -94.61 | 1033 | |
| Sherman | city | Missouri | United States | 38.54 | -90.59 | 830 | |
| Sherrill | city | Missouri | United States | 37.59 | -91.88 | 1145 | |
| Sherwood (historical) | city | Missouri | United States | 37.43 | -94.18 | 1017 | |
| Shibboleth | city | Missouri | United States | 38.01 | -90.71 | 830 | |
| Shibleys Point | city | Missouri | United States | 40.31 | -92.76 | 839 | |
| Shirley | city | Missouri | United States | 37.92 | -90.92 | 997 | |
| Shoal | city | Missouri | United States | 39.65 | -93.93 | 830 | |
| Shoal Creek Drive | city | Missouri | United States | 37.04 | -94.52 | 997 | |
| Shoal Creek Estates | city | Missouri | United States | 37.02 | -94.50 | 921 | |
| Shook | city | Missouri | United States | 37.04 | -90.31 | 830 | |
| Short Bend | city | Missouri | United States | 37.75 | -91.43 | 948 | |
| Shott | city | Missouri | United States | 40.16 | -93.66 | 830 | |
| Shoveltown | city | Missouri | United States | 38.82 | -90.28 | 830 | |
| Shover (historical) | city | Missouri | United States | 36.69 | -90.10 | 318 | |
| Shreve | city | Missouri | United States | 36.65 | -90.10 | 321 | |
| Shrewsbury | city | Missouri | United States | 38.59 | -90.34 | 830 | |
| Shrum | city | Missouri | United States | 37.38 | -90.02 | 830 |