| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Spa | city | Kentucky | United States | 36.96 | -87.00 | 830 | |
| Spaas Creek (historical) | city | Kentucky | United States | 37.86 | -83.71 | 1246 | |
| Spanglin | city | Kentucky | United States | 38.07 | -83.23 | 984 | |
| Spann | city | Kentucky | United States | 36.85 | -84.77 | 1669 | |
| Sparks (historical) | city | Kentucky | United States | 37.72 | -83.77 | 1099 | |
| Sparks (historical) | city | Kentucky | United States | 37.46 | -83.96 | 1669 | |
| Sparksville | city | Kentucky | United States | 37.01 | -85.40 | 1069 | |
| Sparrow | city | Kentucky | United States | 37.92 | -85.15 | 846 | |
| Sparta | city | Kentucky | United States | 38.68 | -84.91 | 830 | |
| Spears | city | Kentucky | United States | 37.87 | -84.44 | 974 | |
| Speck | city | Kentucky | United States | 37.31 | -85.19 | 1053 | |
| Speedwell | city | Kentucky | United States | 37.67 | -84.18 | 958 | |
| Speight | city | Kentucky | United States | 37.28 | -82.69 | 1669 | |
| Spencer Village (historical) | city | Kentucky | United States | 38.03 | -83.84 | 830 | |
| Spice Knob | city | Kentucky | United States | 37.82 | -86.97 | 830 | |
| Spider | city | Kentucky | United States | 37.26 | -82.91 | 1669 | |
| Spike | city | Kentucky | United States | 37.41 | -86.08 | 830 | |
| Spindletop Estates | city | Kentucky | United States | 38.13 | -84.52 | 898 | |
| Spiro | city | Kentucky | United States | 37.34 | -84.40 | 1145 | |
| Sportsmens Paradise | city | Kentucky | United States | 37.36 | -86.09 | 830 | |
| Spottsville | city | Kentucky | United States | 37.86 | -87.41 | 400 | |
| Spout Springs | city | Kentucky | United States | 37.83 | -83.97 | 830 | |
| Spring Creek | city | Kentucky | United States | 37.06 | -83.54 | 1026 | |
| Spring Creek (historical) | city | Kentucky | United States | 37.13 | -88.16 | 390 | |
| Spring Grove | city | Kentucky | United States | 37.68 | -88.03 | 416 | |
| Spring Hill | city | Kentucky | United States | 36.74 | -88.97 | 410 | |
| Spring Hill | city | Kentucky | United States | 37.05 | -88.70 | 416 | |
| Spring Lick | city | Kentucky | United States | 37.44 | -86.56 | 830 | |
| Spring Mill | city | Kentucky | United States | 38.14 | -85.63 | 830 | |
| Spring Ridge (historical) | city | Kentucky | United States | 37.31 | -87.12 | 830 | |
| Spring Valley | city | Kentucky | United States | 38.30 | -85.61 | 830 | |
| Springdale | city | Kentucky | United States | 39.00 | -84.46 | 830 | |
| Springdale | city | Kentucky | United States | 38.62 | -83.67 | 830 | |
| Springdale | city | Kentucky | United States | 38.29 | -85.60 | 830 | |
| Springfield | city | Kentucky | United States | 37.69 | -85.22 | 830 | |
| Springfield Pike (historical) | city | Kentucky | United States | 37.60 | -85.22 | 859 | |
| Springhill | city | Kentucky | United States | 36.98 | -86.48 | 830 | |
| Springlake | city | Kentucky | United States | 39.00 | -84.46 | 830 | |
| Springlee | city | Kentucky | United States | 38.24 | -85.64 | 830 | |
| Sprout | city | Kentucky | United States | 38.30 | -83.89 | 895 | |
| Spruce Pine | city | Kentucky | United States | 36.92 | -83.45 | 1879 | |
| Sprule | city | Kentucky | United States | 37.02 | -83.85 | 1040 | |
| Spurlington | city | Kentucky | United States | 37.41 | -85.27 | 994 | |
| Spurlock | city | Kentucky | United States | 37.21 | -83.63 | 1092 | |
| Spurrier | city | Kentucky | United States | 37.47 | -86.05 | 830 |