| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Spalding (historical) | city | South Carolina | United States | 34.27 | -80.59 | 196 | |
| Spanish Wells | city | South Carolina | United States | 32.19 | -80.78 | 9 | |
| Sparrows Crossroads | city | South Carolina | United States | 34.05 | -79.88 | 95 | |
| Spartanburg | city | South Carolina | United States | 34.95 | -81.93 | 830 | |
| Spaulding Heights | city | South Carolina | United States | 34.22 | -79.76 | 124 | |
| Speaks Mill | city | South Carolina | United States | 32.77 | -81.14 | 118 | |
| Spearman (historical) | city | South Carolina | United States | 34.25 | -81.69 | 830 | |
| Spears Creek | city | South Carolina | United States | 34.12 | -80.72 | 216 | |
| Speigner | city | South Carolina | United States | 33.90 | -81.73 | 830 | |
| Spiderweb | city | South Carolina | United States | 33.41 | -81.83 | 344 | |
| Spring Acres | city | South Carolina | United States | 34.33 | -79.88 | 154 | |
| Spring Branch | city | South Carolina | United States | 34.24 | -79.39 | 98 | |
| Spring Branch (historical) | city | South Carolina | United States | 33.46 | -81.44 | 351 | |
| Spring Brook Terrace | city | South Carolina | United States | 34.78 | -82.41 | 951 | |
| Spring Forest | city | South Carolina | United States | 34.87 | -82.34 | 951 | |
| Spring Forest | city | South Carolina | United States | 34.88 | -82.32 | 1000 | |
| Spring Grove (historical) | city | South Carolina | United States | 34.27 | -81.94 | 830 | |
| Spring Gully | city | South Carolina | United States | 33.39 | -79.41 | 19 | |
| Spring Head (historical) | city | South Carolina | United States | 33.18 | -79.81 | 45 | |
| Spring Hill | city | South Carolina | United States | 34.18 | -81.29 | 390 | |
| Spring Hill | city | South Carolina | United States | 33.99 | -81.17 | 314 | |
| Spring Hill | city | South Carolina | United States | 33.94 | -79.10 | 72 | |
| Spring Hill | city | South Carolina | United States | 34.15 | -80.44 | 347 | |
| Spring Hill | city | South Carolina | United States | 33.23 | -80.32 | 88 | |
| Spring Hill (historical) | city | South Carolina | United States | 33.11 | -79.79 | 29 | |
| Spring Hills | city | South Carolina | United States | 35.03 | -81.97 | 898 | |
| Spring Lake | city | South Carolina | United States | 34.93 | -81.84 | 830 | |
| Spring Lake | city | South Carolina | United States | 34.27 | -80.73 | 360 | |
| Spring Lake | city | South Carolina | United States | 33.88 | -80.39 | 124 | |
| Spring Lake | city | South Carolina | United States | 34.00 | -81.16 | 298 | |
| Spring Park | city | South Carolina | United States | 34.54 | -82.68 | 830 | |
| Spring Plain (historical) | city | South Carolina | United States | 33.38 | -80.18 | 78 | |
| Spring Valley | city | South Carolina | United States | 34.91 | -80.93 | 830 | |
| Spring Valley | city | South Carolina | United States | 34.65 | -82.89 | 830 | |
| Spring Valley | city | South Carolina | United States | 34.11 | -80.93 | 298 | |
| Spring Valley | city | South Carolina | United States | 33.53 | -80.87 | 262 | |
| Spring Village | city | South Carolina | United States | 34.20 | -80.68 | 150 | |
| Springbank Hills | city | South Carolina | United States | 34.00 | -80.51 | 337 | |
| Springbrook | city | South Carolina | United States | 34.67 | -82.96 | 905 | |
| Springdale | city | South Carolina | United States | 33.61 | -81.85 | 830 | |
| Springdale | city | South Carolina | United States | 33.96 | -81.11 | 200 | |
| Springdale | city | South Carolina | United States | 34.95 | -81.88 | 830 | |
| Springdale | city | South Carolina | United States | 34.16 | -82.03 | 830 | |
| Springdale | city | South Carolina | United States | 34.77 | -83.03 | 898 | |
| Springdale | city | South Carolina | United States | 34.69 | -80.79 | 830 | |
| Springdale | city | South Carolina | United States | 35.17 | -82.16 | 918 | |
| Springdale | city | South Carolina | United States | 34.83 | -82.57 | 1013 | |
| Springdale | city | South Carolina | United States | 34.32 | -79.87 | 154 | |
| Springdale Acres | city | South Carolina | United States | 34.93 | -80.96 | 830 | |
| Springdale Estates | city | South Carolina | United States | 35.08 | -81.85 | 830 | |
| Springdale Place | city | South Carolina | United States | 34.19 | -79.87 | 108 | |
| Springdell | city | South Carolina | United States | 34.82 | -80.88 | 830 | |
| Springfield | city | South Carolina | United States | 32.48 | -80.63 | 19 | |
| Springfield | city | South Carolina | United States | 32.84 | -80.05 | 9 | |
| Springfield | city | South Carolina | United States | 33.50 | -81.28 | 291 | |
| Springhill | city | South Carolina | United States | 34.09 | -80.95 | 255 | |
| Springlake | city | South Carolina | United States | 35.06 | -81.93 | 898 | |
| Springmaid Beach | city | South Carolina | United States | 33.66 | -78.92 | 0 | |
| Springs Park | city | South Carolina | United States | 34.61 | -80.88 | 830 | |
| Springstein | city | South Carolina | United States | 34.93 | -80.96 | 830 | |
| Springtown | city | South Carolina | United States | 33.10 | -80.68 | 75 | |
| Springtown | city | South Carolina | United States | 33.22 | -81.10 | 144 | |
| Springville (historical) | city | South Carolina | United States | 34.34 | -79.85 | 150 | |
| Springwood | city | South Carolina | United States | 34.08 | -80.95 | 252 | |
| Springwood Lakes | city | South Carolina | United States | 34.69 | -81.24 | 830 | |
| Sprucewood | city | South Carolina | United States | 32.95 | -80.22 | 9 | |
| Spur | city | South Carolina | United States | 34.17 | -80.30 | 206 |