| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Socastee | city | South Carolina | United States | 33.68 | -79.00 | 19 | |
| Society Hill | city | South Carolina | United States | 34.51 | -79.85 | 124 | |
| Solomons Crossroads | city | South Carolina | United States | 32.79 | -81.32 | 121 | |
| Somerset Point | city | South Carolina | United States | 32.82 | -79.87 | 16 | |
| Sondleys (historical) | city | South Carolina | United States | 34.32 | -81.48 | 830 | |
| South Beach Villas | city | South Carolina | United States | 32.11 | -80.82 | 0 | |
| South Congaree | city | South Carolina | United States | 33.91 | -81.14 | 196 | |
| South Cove | city | South Carolina | United States | 34.72 | -82.96 | 830 | |
| South Forest Estates | city | South Carolina | United States | 34.78 | -82.38 | 921 | |
| South Greenwood | city | South Carolina | United States | 34.16 | -82.14 | 830 | |
| South Hills | city | South Carolina | United States | 34.69 | -81.61 | 830 | |
| South Lynchburg | city | South Carolina | United States | 34.05 | -80.06 | 141 | |
| South Meadows Farms | city | South Carolina | United States | 34.92 | -81.95 | 830 | |
| South Park | city | South Carolina | United States | 34.16 | -79.80 | 118 | |
| South Park | city | South Carolina | United States | 34.36 | -80.07 | 226 | |
| South Point | city | South Carolina | United States | 34.15 | -79.81 | 118 | |
| South Point | city | South Carolina | United States | 35.09 | -81.06 | 830 | |
| South Pointe | city | South Carolina | United States | 33.02 | -80.15 | 75 | |
| South Santee | city | South Carolina | United States | 33.17 | -79.42 | 19 | |
| South Sea Pines | city | South Carolina | United States | 32.11 | -80.82 | 0 | |
| South Side | city | South Carolina | United States | 34.13 | -79.76 | 91 | |
| South Sumter | city | South Carolina | United States | 33.91 | -80.35 | 167 | |
| South Union | city | South Carolina | United States | 34.55 | -83.05 | 843 | |
| South Windermire | city | South Carolina | United States | 32.78 | -79.98 | 3 | |
| Southeast Newberry | city | South Carolina | United States | 34.25 | -81.57 | 830 | |
| Southern Meadows | city | South Carolina | United States | 34.67 | -82.93 | 830 | |
| Southern Palms | city | South Carolina | United States | 32.98 | -80.13 | 49 | |
| Southern Pines | city | South Carolina | United States | 34.98 | -81.84 | 830 | |
| Southern Shops | city | South Carolina | United States | 34.99 | -81.99 | 875 | |
| Southgate | city | South Carolina | United States | 33.84 | -80.38 | 173 | |
| Southgate | city | South Carolina | United States | 33.94 | -81.22 | 269 | |
| Southland Park | city | South Carolina | United States | 34.89 | -81.02 | 830 | |
| Southport Estates | city | South Carolina | United States | 34.90 | -81.97 | 830 | |
| Southwood | city | South Carolina | United States | 33.52 | -81.77 | 830 |