| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| Sadler (historical) | city | South Carolina | United States | 34.44 | -82.83 | 830 | |
| Saint Andrews | city | South Carolina | United States | 34.05 | -81.13 | 272 | |
| Saint Andrews | city | South Carolina | United States | 32.78 | -79.99 | 6 | |
| Saint Andrews | city | South Carolina | United States | 34.05 | -81.10 | 301 | |
| Saint Andrews Heights | city | South Carolina | United States | 32.79 | -80.01 | 9 | |
| Saint Charles | city | South Carolina | United States | 34.07 | -80.22 | 160 | |
| Saint George | city | South Carolina | United States | 33.19 | -80.58 | 98 | |
| Saint James Estates | city | South Carolina | United States | 32.96 | -80.01 | 29 | |
| Saint Johns | city | South Carolina | United States | 33.12 | -80.07 | 49 | |
| Saint Johns Crossroads | city | South Carolina | United States | 33.78 | -79.50 | 62 | |
| Saint Julian | city | South Carolina | United States | 33.41 | -80.36 | 98 | |
| Saint Marks Wood | city | South Carolina | United States | 33.98 | -80.94 | 298 | |
| Saint Matthews | city | South Carolina | United States | 33.66 | -80.78 | 278 | |
| Saint Paul | city | South Carolina | United States | 33.58 | -80.39 | 88 | |
| Saint Paul Forks | city | South Carolina | United States | 33.89 | -79.04 | 26 | |
| Saint Pauls | city | South Carolina | United States | 33.58 | -79.19 | 19 | |
| Saint Phillips | city | South Carolina | United States | 34.30 | -81.51 | 416 | |
| Saint Stephen | city | South Carolina | United States | 33.40 | -79.92 | 72 | |
| Salak | city | South Carolina | United States | 34.16 | -82.21 | 830 | |
| Salem | city | South Carolina | United States | 34.89 | -82.98 | 1099 | |
| Salem | city | South Carolina | United States | 34.53 | -79.70 | 124 | |
| Salem | city | South Carolina | United States | 33.96 | -79.80 | 91 | |
| Salem | city | South Carolina | United States | 33.89 | -79.51 | 59 | |
| Salem Crossroads | city | South Carolina | United States | 34.42 | -81.30 | 830 | |
| Salem Crossroads | city | South Carolina | United States | 33.95 | -79.13 | 78 | |
| Salem Estates | city | South Carolina | United States | 34.90 | -81.97 | 830 | |
| Salem Plantation | city | South Carolina | United States | 32.42 | -80.71 | 3 | |
| Salisbury Acres | city | South Carolina | United States | 32.99 | -80.20 | 52 | |
| Salkehatchie | city | South Carolina | United States | 32.71 | -80.81 | 9 | |
| Salley | city | South Carolina | United States | 33.57 | -81.30 | 334 | |
| Salt Creek | city | South Carolina | United States | 32.45 | -80.73 | 3 | |
| Salt Marsh Cove | city | South Carolina | United States | 33.47 | -79.11 | 6 | |
| Salters | city | South Carolina | United States | 33.60 | -79.85 | 49 | |
| Salters Depot | city | South Carolina | United States | 33.60 | -79.85 | 49 | |
| Saluca | city | South Carolina | United States | 34.23 | -82.06 | 830 | |
| Saluda | city | South Carolina | United States | 34.00 | -81.77 | 830 | |
| Saluda Gardens | city | South Carolina | United States | 34.01 | -81.08 | 232 | |
| Saluda Hills | city | South Carolina | United States | 34.01 | -81.11 | 278 | |
| Saluda River Estates | city | South Carolina | United States | 34.00 | -81.07 | 252 | |
| Saluda Terrace | city | South Carolina | United States | 34.01 | -81.09 | 232 | |
| Salvesbarg Landing | city | South Carolina | United States | 32.48 | -80.85 | 9 | |
| Samaria | city | South Carolina | United States | 33.83 | -81.48 | 830 | |
| Sampit | city | South Carolina | United States | 33.36 | -79.46 | 19 | |
| Sampson | city | South Carolina | United States | 34.87 | -82.41 | 1007 | |
| Sampson Landing | city | South Carolina | United States | 33.80 | -79.26 | 19 | |
| San Marco Estates | city | South Carolina | United States | 33.97 | -80.85 | 298 | |
| San Mateo | city | South Carolina | United States | 34.52 | -82.72 | 830 | |
| San Miguel De Gualdape (historical) | city | South Carolina | United States | 33.33 | -79.26 | 16 | |
| Sand Ridge | city | South Carolina | United States | 34.06 | -82.01 | 830 | |
| Sand Ridge | city | South Carolina | United States | 33.82 | -79.09 | 32 | |
| Sanders (historical) | city | South Carolina | United States | 32.96 | -81.30 | 124 | |
| Sanders Corner | city | South Carolina | United States | 34.00 | -80.54 | 190 | |
| Sanders Subdivision | city | South Carolina | United States | 33.91 | -80.41 | 180 | |
| Sandhurst | city | South Carolina | United States | 32.82 | -80.00 | 6 | |
| Sandhurst | city | South Carolina | United States | 34.16 | -79.79 | 118 | |
| Sandlewood | city | South Carolina | United States | 33.55 | -81.91 | 351 | |
| Sandridge | city | South Carolina | United States | 34.25 | -79.72 | 88 | |
| Sandridge | city | South Carolina | United States | 33.26 | -80.32 | 85 | |
| Sandwood | city | South Carolina | United States | 34.05 | -80.95 | 249 | |
| Sandwood Hills | city | South Carolina | United States | 34.21 | -80.74 | 308 | |
| Sandy | city | South Carolina | United States | 32.82 | -80.08 | 9 | |
| Sandy Flat | city | South Carolina | United States | 34.99 | -82.34 | 1000 | |
| Sandy River | city | South Carolina | United States | 34.66 | -81.33 | 830 | |
| Sandy Run | city | South Carolina | United States | 33.32 | -80.72 | 144 | |
| Sandy Run | city | South Carolina | United States | 33.80 | -80.96 | 200 | |
| Sandy Run (historical) | city | South Carolina | United States | 33.13 | -80.17 | 49 | |
| Sandy Springs | city | South Carolina | United States | 34.29 | -80.62 | 278 | |
| Sandy Springs | city | South Carolina | United States | 34.60 | -82.75 | 830 | |
| Sangaree | city | South Carolina | United States | 33.04 | -80.13 | 55 | |
| Sangster Village | city | South Carolina | United States | 32.42 | -80.66 | 9 | |
| Sans Souci | city | South Carolina | United States | 34.88 | -82.42 | 938 | |
| Sans Souci Heights | city | South Carolina | United States | 34.90 | -82.42 | 997 | |
| Sansbury Crossroads | city | South Carolina | United States | 34.06 | -79.92 | 98 | |
| Santa Elena (historical) | city | South Carolina | United States | 32.31 | -80.68 | 3 | |
| Santarosa | city | South Carolina | United States | 34.68 | -80.78 | 830 | |
| Santee | city | South Carolina | United States | 33.48 | -80.49 | 134 | |
| Santee (historical) | city | South Carolina | United States | 33.45 | -79.90 | 19 | |
| Santee Circle | city | South Carolina | United States | 33.24 | -79.96 | 49 | |
| Santuc | city | South Carolina | United States | 34.63 | -81.52 | 830 | |
| Sapps Crossroads | city | South Carolina | United States | 34.81 | -80.63 | 830 | |
| Saratt | city | South Carolina | United States | 34.90 | -81.54 | 830 | |
| Sardinia | city | South Carolina | United States | 33.83 | -80.08 | 104 | |
| Sardis | city | South Carolina | United States | 34.67 | -81.63 | 830 | |
| Sardis | city | South Carolina | United States | 34.04 | -79.94 | 121 | |
| Sartor Estates | city | South Carolina | United States | 34.31 | -79.86 | 150 | |
| Sartor Town | city | South Carolina | United States | 34.52 | -81.54 | 400 | |
| Sarvis Crossroads | city | South Carolina | United States | 34.04 | -78.97 | 101 | |
| Satchel Ford Terrace | city | South Carolina | United States | 34.06 | -80.97 | 200 | |
| Sato | city | South Carolina | United States | 33.32 | -81.13 | 236 | |
| Savanna Creek | city | South Carolina | United States | 33.29 | -79.76 | 32 | |
| Savanna Town (historical) | city | South Carolina | United States | 33.43 | -81.91 | 154 | |
| Savannah Grove | city | South Carolina | United States | 34.15 | -79.83 | 118 | |
| Savannah Terrace | city | South Carolina | United States | 33.50 | -81.98 | 180 | |
| Saw Mill | city | South Carolina | United States | 33.12 | -79.90 | 29 | |
| Sawmill Terrace | city | South Carolina | United States | 33.01 | -80.17 | 75 | |
| Sawyerdale | city | South Carolina | United States | 33.59 | -81.23 | 390 | |
| Saxon | city | South Carolina | United States | 34.96 | -81.97 | 830 | |
| Saxony Forest | city | South Carolina | United States | 34.77 | -82.96 | 889 | |
| Saxton Homes | city | South Carolina | United States | 34.02 | -81.02 | 298 | |
| Saylors Crossroads | city | South Carolina | United States | 34.40 | -82.51 | 830 |