| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Saint Charles | city | South Dakota | United States | 43.08694 | -99.095 | 2073 | 182 |
| Saint Francis | city | South Dakota | United States | 43.14444 | -100.90472 | 3008 | 378 |
| Saint Lawrence | city | South Dakota | United States | 44.51778 | -98.9375 | 1574 | 1307 |
| Saint Onge | city | South Dakota | United States | 44.54667 | -103.72056 | 3448 | 803 |
| Salem | city | South Dakota | United States | 43.72417 | -97.38861 | 1538 | 476 |
| Sanator | city | South Dakota | United States | 43.69667 | -103.60528 | 5396 | 941 |
| Sand Hill Subdivision | city | South Dakota | United States | 43.70278 | -98.04583 | 1361 | 6414 |
| Sansarc | city | South Dakota | United States | 44.50667 | -101.03444 | 2099 | 75 |
| Savoy | city | South Dakota | United States | 44.3525 | -103.93083 | 5180 | 1522 |
| Saybrook historical | city | South Dakota | United States | 42.93889 | -97.14306 | 1187 | 359 |
| Scenic | city | South Dakota | United States | 43.77972 | -102.55444 | 2808 | 84 |
| Schaeferville | city | South Dakota | United States | 44.12139 | -103.295 | 3553 | 13580 |
| Schmidt Landing | city | South Dakota | United States | 45.37972 | -96.56056 | 964 | 348 |
| Scotland | city | South Dakota | United States | 43.14972 | -97.71722 | 1299 | 559 |
| Selby | city | South Dakota | United States | 45.50639 | -100.03167 | 1899 | 112 |
| Seneca | city | South Dakota | United States | 45.06167 | -99.51167 | 1893 | 113 |
| Sevenmile Corner | city | South Dakota | United States | 43.83583 | -101.66 | 2493 | 75 |
| Shadehill | city | South Dakota | United States | 45.76556 | -102.17889 | 2240 | 56 |
| Shady Beach | city | South Dakota | United States | 45.40361 | -96.63167 | 1056 | 345 |
| Sharps Corner | city | South Dakota | United States | 43.38972 | -102.39806 | 2998 | 238 |
| Shaw historical | city | South Dakota | United States | 43.07917 | -97.15833 | 1417 | 404 |
| Sheffield | city | South Dakota | United States | 44.41306 | -98.07361 | 1302 | 606 |
| Shelby | city | South Dakota | United States | 43.94806 | -99.18694 | 1473 | 152 |
| Sheldon Trailor Town | city | South Dakota | United States | 44.26889 | -96.81583 | 1594 | 10438 |
| Sheridan historical | city | South Dakota | United States | 43.97694 | -103.47 | 4799 | 313 |
| Sherman | city | South Dakota | United States | 43.75917 | -96.47583 | 1489 | 1222 |
| Shindler | city | South Dakota | United States | 43.475 | -96.64833 | 1374 | 14476 |
| Silver City | city | South Dakota | United States | 44.08444 | -103.56333 | 4740 | 284 |
| Silver Valley Addition | city | South Dakota | United States | 43.53361 | -96.80722 | 1466 | 33437 |
| Sinai | city | South Dakota | United States | 44.24444 | -97.04056 | 1735 | 412 |
| Sioux Falls | city | South Dakota | United States | 43.55 | -96.7 | 1499 | 59464 |
| Sioux Falls Junction | city | South Dakota | United States | 43.97917 | -96.68917 | 1528 | 988 |
| Sioux Village | city | South Dakota | United States | 44.11444 | -103.21722 | 3293 | 38939 |
| Sisseton | city | South Dakota | United States | 45.66472 | -97.04944 | 1200 | 2239 |
| Sitka | city | South Dakota | United States | 45.51694 | -100.18583 | 1899 | 112 |
| Skyline Heights | city | South Dakota | United States | 43.60694 | -96.76139 | 1466 | 20375 |
| Slim Butte | city | South Dakota | United States | 43.07611 | -102.82028 | 2998 | 238 |
| Smiths Park | city | South Dakota | United States | 43.935 | -96.99667 | 1597 | 504 |
| Smithwick | city | South Dakota | United States | 43.30139 | -103.21778 | 3343 | 61 |
| Snake Creek | city | South Dakota | United States | 45.58472 | -100.58556 | 1699 | 70 |
| Snoma historical | city | South Dakota | United States | 44.64833 | -103.69167 | 2985 | 182 |
| Soldier Creek | city | South Dakota | United States | 43.32361 | -100.88778 | 2381 | 369 |
| Sorum | city | South Dakota | United States | 45.44972 | -102.92889 | 2801 | 42 |
| Sorum Addition | city | South Dakota | United States | 43.65111 | -96.71306 | 1469 | 3801 |
| Sorum Heights | city | South Dakota | United States | 43.65417 | -96.70861 | 1489 | 3801 |
| South Canyon Country Estates | city | South Dakota | United States | 44.10194 | -103.3625 | 3966 | 5376 |
| South Dakota Park | city | South Dakota | United States | 45.4175 | -96.70056 | 974 | 349 |
| South Shore | city | South Dakota | United States | 45.10583 | -96.92833 | 1902 | 304 |
| Spain | city | South Dakota | United States | 45.70306 | -97.78556 | 1332 | 229 |
| Spearfish | city | South Dakota | United States | 44.49083 | -103.85889 | 3727 | 6400 |
| Spencer | city | South Dakota | United States | 43.7275 | -97.59278 | 1397 | 386 |
| Spink | city | South Dakota | United States | 42.85194 | -96.74667 | 1227 | 813 |
| Spink Colony | city | South Dakota | United States | 44.74667 | -98.29167 | 1276 | 167 |
| Split Rock Heights | city | South Dakota | United States | 43.52806 | -96.64944 | 1489 | 29390 |
| Spokane | city | South Dakota | United States | 43.84139 | -103.37944 | 4432 | 208 |
| Spottswood | city | South Dakota | United States | 44.65222 | -98.50528 | 1328 | 165 |
| Spring Creek | city | South Dakota | United States | 43.1175 | -101.02222 | 2798 | 378 |
| Spring Creek Colony | city | South Dakota | United States | 45.90917 | -98.87833 | 1633 | 102 |
| Spring Grove | city | South Dakota | United States | 45.46306 | -97.04972 | 1620 | 281 |
| Spring Valley | city | South Dakota | United States | 43.20417 | -97.26861 | 1548 | 517 |
| Spring Valley Colony | city | South Dakota | United States | 44.04056 | -98.88667 | 1650 | 115 |
| Springfield | city | South Dakota | United States | 42.85417 | -97.89694 | 1266 | 395 |
| Stamford | city | South Dakota | United States | 43.895 | -101.08861 | 2398 | 70 |
| Stanley Corner | city | South Dakota | United States | 43.54333 | -97.3875 | 1450 | 378 |
| Star Corner historical | city | South Dakota | United States | 43.04028 | -97.06389 | 1292 | 336 |
| State Game Lodge | city | South Dakota | United States | 43.77111 | -103.38333 | 4416 | 112 |
| Stephan | city | South Dakota | United States | 44.24806 | -99.45278 | 1801 | 97 |
| Stickney | city | South Dakota | United States | 43.58917 | -98.43694 | 1650 | 145 |
| Stockholm | city | South Dakota | United States | 45.09972 | -96.80167 | 1686 | 187 |
| Stone Bridge | city | South Dakota | United States | 44.60222 | -97.05944 | 1643 | 518 |
| Stoneville | city | South Dakota | United States | 44.73361 | -102.65417 | 2972 | 33 |
| Storla | city | South Dakota | United States | 43.86361 | -98.35111 | 1377 | 215 |
| Strandburg | city | South Dakota | United States | 45.04417 | -96.76028 | 1646 | 187 |
| Stratford | city | South Dakota | United States | 45.31639 | -98.30444 | 1299 | 280 |
| Stratosphere Bowl | city | South Dakota | United States | 43.97667 | -103.34528 | 4271 | 2026 |
| Strool | city | South Dakota | United States | 45.50056 | -102.80444 | 2900 | 56 |
| Sturgis | city | South Dakota | United States | 44.40972 | -103.50861 | 3556 | 6865 |
| Success historical | city | South Dakota | United States | 44.57056 | -97.53611 | 1748 | 225 |
| Sulphur | city | South Dakota | United States | 44.87667 | -102.91306 | 2723 | 33 |
| Summerville | city | South Dakota | United States | 45.77389 | -102.17694 | 2244 | 56 |
| Summit | city | South Dakota | United States | 45.30444 | -97.03611 | 1975 | 374 |
| Sundahl Trailer Court | city | South Dakota | United States | 44.34139 | -96.77722 | 1604 | 10494 |
| Sunnyview | city | South Dakota | United States | 44.34472 | -96.785 | 1601 | 10494 |
| Sweetland historical | city | South Dakota | United States | 44.34056 | -98.98444 | 1893 | 61 |
| Swett | city | South Dakota | United States | 43.17194 | -101.95111 | 3346 | 117 |
| Sylvan Lake Resort | city | South Dakota | United States | 43.84611 | -103.56389 | 6200 | 811 |
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