| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Eagle | city | South Dakota | United States | 43.57194 | -99.09056 | 1748 | 145 |
| Eagle Butte | city | South Dakota | United States | 45.0025 | -101.23306 | 2454 | 86 |
| Eakin | city | South Dakota | United States | 44.61556 | -100.03278 | 1781 | 64 |
| East Sioux Falls | city | South Dakota | United States | 43.52694 | -96.60833 | 1299 | 7748 |
| Eden | city | South Dakota | United States | 45.61667 | -97.41944 | 1847 | 219 |
| Edgemont | city | South Dakota | United States | 43.30111 | -103.825 | 3592 | 61 |
| Egan | city | South Dakota | United States | 43.99917 | -96.64861 | 1525 | 1226 |
| El Rancho Acres | city | South Dakota | United States | 43.50139 | -96.87278 | 1512 | 14867 |
| Elbon | city | South Dakota | United States | 44.28083 | -101.68806 | 2529 | 56 |
| Elevenmile Corner | city | South Dakota | United States | 44.19722 | -101.66722 | 2391 | 56 |
| Elizabethtown historical | city | South Dakota | United States | 44.3875 | -103.70278 | 4753 | 932 |
| Elk Point | city | South Dakota | United States | 42.68333 | -96.68333 | 1125 | 962 |
| Elkton | city | South Dakota | United States | 44.23611 | -96.48083 | 1751 | 462 |
| Ellingson historical | city | South Dakota | United States | 45.86667 | -102.86944 | 2700 | 56 |
| Ellis | city | South Dakota | United States | 43.5625 | -96.83028 | 1450 | 31642 |
| Ellis Corner | city | South Dakota | United States | 43.60167 | -96.83056 | 1476 | 9861 |
| Elm Springs | city | South Dakota | United States | 44.31333 | -102.52722 | 2627 | 42 |
| Elmore | city | South Dakota | United States | 44.31556 | -103.88694 | 5597 | 1878 |
| Elrod | city | South Dakota | United States | 44.88639 | -97.57333 | 1804 | 212 |
| Emery | city | South Dakota | United States | 43.60167 | -97.62222 | 1387 | 333 |
| Emmet | city | South Dakota | United States | 42.98278 | -96.74583 | 1292 | 789 |
| Empire | city | South Dakota | United States | 44.6175 | -103.32083 | 2791 | 118 |
| Englewood | city | South Dakota | United States | 44.29694 | -103.78417 | 5997 | 1481 |
| Enning | city | South Dakota | United States | 44.57556 | -102.56278 | 3054 | 33 |
| Epiphany | city | South Dakota | United States | 43.84917 | -97.66139 | 1384 | 206 |
| Erickson Subdivision | city | South Dakota | United States | 43.60806 | -96.71056 | 1466 | 26031 |
| Erskine | city | South Dakota | United States | 43.43306 | -103.56444 | 3851 | 768 |
| Erwin | city | South Dakota | United States | 44.4875 | -97.44472 | 1850 | 304 |
| Esmond | city | South Dakota | United States | 44.26222 | -97.77111 | 1423 | 257 |
| Estelline | city | South Dakota | United States | 44.57472 | -96.90194 | 1679 | 414 |
| Ethan | city | South Dakota | United States | 43.54778 | -97.98778 | 1338 | 291 |
| Eureka | city | South Dakota | United States | 45.76944 | -99.61917 | 1889 | 109 |
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