| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| O'Neal | city | South Carolina | United States | 35.00722 | -82.28111 | 961 | 10423 |
| Oak Corner | city | South Carolina | United States | 33.16889 | -79.70833 | 36 | 538 |
| Oak Creek | city | South Carolina | United States | 34.83556 | -82.25139 | 898 | 44539 |
| Oak Creek | city | South Carolina | United States | 34.93139 | -81.85583 | 731 | 31375 |
| Oak Creek | city | South Carolina | United States | 34.02139 | -81.1375 | 203 | 63198 |
| Oak Crest | city | South Carolina | United States | 34.82472 | -82.44111 | 951 | 73732 |
| Oak Crest | city | South Carolina | United States | 33.99028 | -81.16472 | 314 | 46753 |
| Oak Dale subdivision | city | South Carolina | United States | 34.31611 | -79.85556 | 150 | 14667 |
| Oak Forest | city | South Carolina | United States | 34.90944 | -81.99444 | 800 | 38687 |
| Oak Forest | city | South Carolina | United States | 34.18167 | -79.86444 | 111 | 21756 |
| Oak Forest subdivision | city | South Carolina | United States | 32.78639 | -79.99972 | 6 | 85931 |
| Oak Grove | city | South Carolina | United States | 33.74889 | -81.52444 | 495 | 1251 |
| Oak Grove | city | South Carolina | United States | 33.77806 | -80.96694 | 249 | 2502 |
| Oak Grove | city | South Carolina | United States | 34.14083 | -79.56972 | 98 | 2349 |
| Oak Grove | city | South Carolina | United States | 34.35139 | -79.54278 | 98 | 2025 |
| Oak Grove | city | South Carolina | United States | 33.38583 | -79.46083 | 26 | 3197 |
| Oak Grove Estates | city | South Carolina | United States | 33.98056 | -81.15833 | 360 | 46753 |
| Oak Grove subdivision | city | South Carolina | United States | 32.90278 | -80.01583 | 39 | 79406 |
| Oak Haven Acres | city | South Carolina | United States | 33.9125 | -80.41083 | 180 | 35196 |
| Oak Hill | city | South Carolina | United States | 33.44389 | -81.69472 | 429 | 5967 |
| Oak Hill | city | South Carolina | United States | 33.1875 | -80.01889 | 49 | 8274 |
| Oak Hill | city | South Carolina | United States | 33.54167 | -79.06472 | 19 | 7169 |
| Oak Hills subdivision | city | South Carolina | United States | 34.87639 | -82.44722 | 1020 | 67445 |
| Oak Hollow | city | South Carolina | United States | 34.94361 | -82.36944 | 1026 | 40457 |
| Oak Hurst | city | South Carolina | United States | 34.93139 | -81.89528 | 770 | 53656 |
| Oak Knoll Estates subdivision | city | South Carolina | United States | 33.00111 | -80.1725 | 75 | 45979 |
| Oak Park | city | South Carolina | United States | 33.145 | -80.0625 | 68 | 7062 |
| Oak Park subdivision | city | South Carolina | United States | 33.71944 | -78.84944 | 0 | 18743 |
| Oak Ridge | city | South Carolina | United States | 33.42083 | -79.64444 | 39 | 1085 |
| Oak Ridge subdivision | city | South Carolina | United States | 32.85611 | -80.03944 | 19 | 91179 |
| Oak View | city | South Carolina | United States | 34.91722 | -82.28833 | 889 | 40607 |
| Oakatee | city | South Carolina | United States | 33.04167 | -80.07917 | 42 | 22903 |
| Oakbrook | city | South Carolina | United States | 32.95833 | -80.17222 | 9 | 25596 |
| Oakcrest | city | South Carolina | United States | 32.72389 | -79.96111 | 13 | 46918 |
| Oakdale | city | South Carolina | United States | 34.53278 | -82.84611 | 777 | 4227 |
| Oakdale | city | South Carolina | United States | 34.88 | -81.05139 | 600 | 29440 |
| Oakdale | city | South Carolina | United States | 34.17361 | -79.88722 | 134 | 9368 |
| Oakdale Acres | city | South Carolina | United States | 34.87722 | -81.05222 | 534 | 29440 |
| Oakdale Estates | city | South Carolina | United States | 32.99583 | -80.21333 | 29 | 27209 |
| Oakey Bay | city | South Carolina | United States | 33.84361 | -79.13333 | 39 | 6028 |
| Oakgrove | city | South Carolina | United States | 32.62667 | -80.21306 | 9 | 2826 |
| Oakhurst | city | South Carolina | United States | 34.58 | -80.64694 | 600 | 2335 |
| Oakland | city | South Carolina | United States | 33.98278 | -80.48861 | 308 | 21285 |
| Oakland | city | South Carolina | United States | 32.78528 | -80.03528 | 3 | 58099 |
| Oakland Crossroads | city | South Carolina | United States | 34.53889 | -79.36639 | 137 | 2717 |
| Oakland Heights subdivision | city | South Carolina | United States | 33.74333 | -78.83056 | 19 | 12536 |
| Oaklawn | city | South Carolina | United States | 33.94694 | -80.34583 | 157 | 42737 |
| Oakley | city | South Carolina | United States | 33.12389 | -80.01917 | 9 | 6540 |
| Oakmont | city | South Carolina | United States | 34.78 | -83.03056 | 984 | 9726 |
| Oakmont | city | South Carolina | United States | 33.56667 | -80.95222 | 242 | 6560 |
| Oakmont | city | South Carolina | United States | 32.40139 | -80.76806 | 6 | 12998 |
| Oakmont | city | South Carolina | United States | 32.96528 | -80.14472 | 29 | 56779 |
| Oakridge | city | South Carolina | United States | 33.91667 | -81.22333 | 400 | 18702 |
| Oaks Crossroads | city | South Carolina | United States | 33.45833 | -80.62472 | 127 | 2382 |
| Oakview Park | city | South Carolina | United States | 32.74194 | -79.98278 | 3 | 46918 |
| Oakway | city | South Carolina | United States | 34.60111 | -83.02583 | 961 | 4330 |
| Oakwood | city | South Carolina | United States | 34.94389 | -82.20278 | 905 | 23807 |
| Oakwood | city | South Carolina | United States | 33.51639 | -81.58639 | 429 | 4697 |
| Oakwood | city | South Carolina | United States | 33.97639 | -81.15417 | 351 | 46753 |
| Oakwood | city | South Carolina | United States | 35.10528 | -81.06333 | 610 | 8966 |
| Oakwood Acres subdivision | city | South Carolina | United States | 34.97111 | -81.00694 | 597 | 45311 |
| Oakwood Estates | city | South Carolina | United States | 34.55833 | -82.66472 | 672 | 27558 |
| Oakwood Park | city | South Carolina | United States | 32.42083 | -80.64194 | 3 | 14162 |
| Oatland | city | South Carolina | United States | 33.495 | -79.3475 | 19 | 4897 |
| Oats | city | South Carolina | United States | 34.25333 | -80.07778 | 180 | 2981 |
| Obed historical | city | South Carolina | United States | 35.15306 | -82.09333 | 997 | 5582 |
| Ocean Drive Beach | city | South Carolina | United States | 33.81833 | -78.67361 | 0 | 9867 |
| Ocean Forest | city | South Carolina | United States | 33.72972 | -78.83833 | 9 | 18743 |
| Ocean Lakes | city | South Carolina | United States | 33.62583 | -78.95389 | 0 | 27835 |
| Ocean Pines | city | South Carolina | United States | 33.59028 | -79.0125 | 13 | 18756 |
| Oceanmarsh Subdivision | city | South Carolina | United States | 32.39806 | -80.43944 | 3 | 745 |
| Oceanside Village | city | South Carolina | United States | 33.59444 | -78.99111 | 3 | 20191 |
| Oceanview | city | South Carolina | United States | 32.71778 | -79.93389 | 3 | 50215 |
| Oceda | city | South Carolina | United States | 33.35139 | -79.63722 | 22 | 865 |
| Oconee Estates | city | South Carolina | United States | 34.70417 | -83.00694 | 823 | 9163 |
| Oconee Point | city | South Carolina | United States | 34.59806 | -82.86889 | 656 | 12446 |
| Ogden | city | South Carolina | United States | 34.8625 | -81.09472 | 508 | 5758 |
| Okatie | city | South Carolina | United States | 32.35194 | -80.97833 | 9 | 1590 |
| Olanta | city | South Carolina | United States | 33.93528 | -79.93278 | 111 | 2849 |
| Olar | city | South Carolina | United States | 33.18028 | -81.18556 | 193 | 1371 |
| Old Buckhead | city | South Carolina | United States | 34.45 | -81.30111 | 475 | 745 |
| Old Cordesville | city | South Carolina | United States | 33.1775 | -79.91694 | 42 | 3315 |
| Old Court | city | South Carolina | United States | 34.18222 | -79.8775 | 124 | 9368 |
| Old Farm subdivision | city | South Carolina | United States | 34.94778 | -81.04806 | 636 | 44128 |
| Old Forest subdivision | city | South Carolina | United States | 34.04806 | -80.98139 | 282 | 90297 |
| Old Fort Estates | city | South Carolina | United States | 32.9575 | -80.13028 | 29 | 35340 |
| Old House | city | South Carolina | United States | 32.45944 | -80.89667 | 3 | 1637 |
| Old Joe | city | South Carolina | United States | 33.05556 | -79.80806 | 36 | 1050 |
| Old Madison | city | South Carolina | United States | 34.6125 | -83.19639 | 656 | 4632 |
| Old Mill Estates | city | South Carolina | United States | 34.92944 | -82.30944 | 872 | 43065 |
| Old Morrisville | city | South Carolina | United States | 33.59833 | -79.5075 | 42 | 1192 |
| Old Orchard | city | South Carolina | United States | 32.72111 | -79.94306 | 3 | 50215 |
| Old Orchid subdivision | city | South Carolina | United States | 35.00083 | -80.95611 | 603 | 16537 |
| Old Peru | city | South Carolina | United States | 33.42028 | -79.98694 | 75 | 2061 |
| Old Pickens | city | South Carolina | United States | 34.78611 | -82.88889 | 764 | 9748 |
| Old Point Station | city | South Carolina | United States | 34.95972 | -81.04889 | 669 | 36844 |
| Old River Estates | city | South Carolina | United States | 33.85278 | -78.64167 | 22 | 9869 |
| Old Saint George | city | South Carolina | United States | 33.17111 | -80.6125 | 82 | 2895 |
| Old Town | city | South Carolina | United States | 32.80444 | -79.98472 | 3 | 100956 |
| Old Vat historical | city | South Carolina | United States | 32.93167 | -79.84861 | 16 | 1758 |
| Oldtown historical | city | South Carolina | United States | 34.17333 | -81.78194 | 387 | 1818 |
| Oldwoods | city | South Carolina | United States | 34.9625 | -81.06972 | 623 | 36844 |
| Ole Salem Estates | city | South Carolina | United States | 34.91222 | -82.55194 | 1000 | 11131 |
| Olga historical | city | South Carolina | United States | 35.00278 | -82.55861 | 977 | 3001 |
| Olin | city | South Carolina | United States | 33.425 | -79.46528 | 26 | 4400 |
| Oliver Crossroads | city | South Carolina | United States | 34.38444 | -79.26389 | 101 | 3437 |
| Olympia | city | South Carolina | United States | 33.97639 | -81.03 | 150 | 101570 |
| Opossum Point Landing | city | South Carolina | United States | 32.17694 | -80.77306 | 3 | 17554 |
| Ora | city | South Carolina | United States | 34.58167 | -81.99583 | 708 | 5097 |
| Orange Grove | city | South Carolina | United States | 32.40028 | -80.66222 | 9 | 16299 |
| Orange Grove Estates subdivision | city | South Carolina | United States | 32.8175 | -80.00028 | 6 | 80072 |
| Orangeburg | city | South Carolina | United States | 33.49167 | -80.85583 | 203 | 21335 |
| Orangeburg Manor subdivision | city | South Carolina | United States | 33.47778 | -80.85806 | 200 | 21335 |
| Orangewood subdivision | city | South Carolina | United States | 33.47944 | -80.81167 | 180 | 16510 |
| Orchard Acres | city | South Carolina | United States | 34.90806 | -82.3225 | 997 | 68165 |
| Orchard Hill | city | South Carolina | United States | 33.02528 | -80.22278 | 65 | 30975 |
| Orchard Park | city | South Carolina | United States | 34.85417 | -82.32361 | 1010 | 73609 |
| Orleans Estates subdivision | city | South Carolina | United States | 32.79667 | -80.02722 | 9 | 80072 |
| Orleans Woods subdivision | city | South Carolina | United States | 32.80333 | -80.025 | 9 | 80072 |
| Orrs | city | South Carolina | United States | 34.71694 | -81.12361 | 538 | 1539 |
| Orum | city | South Carolina | United States | 34.08194 | -79.56833 | 91 | 1786 |
| Osborn | city | South Carolina | United States | 32.75556 | -80.34639 | 29 | 1697 |
| Osceola Heights subdivision | city | South Carolina | United States | 32.78667 | -79.85944 | 3 | 24492 |
| Osceola Oaks subdivision | city | South Carolina | United States | 32.78806 | -79.86167 | 3 | 24492 |
| Oswald Park | city | South Carolina | United States | 34.035 | -81.41361 | 400 | 3726 |
| Oswald Place | city | South Carolina | United States | 32.71944 | -79.93861 | 3 | 50215 |
| Oswego | city | South Carolina | United States | 34.00722 | -80.28778 | 147 | 3635 |
| Otranto | city | South Carolina | United States | 32.965 | -80.04444 | 26 | 61178 |
| Ott historical | city | South Carolina | United States | 33.3125 | -81.09361 | 200 | 3559 |
| Otter Hole | city | South Carolina | United States | 32.195 | -80.73389 | 3 | 17943 |
| Outland | city | South Carolina | United States | 33.72667 | -79.37278 | 49 | 2485 |
| Overbrook | city | South Carolina | United States | 34.85972 | -82.37806 | 898 | 108112 |
| Owdoms | city | South Carolina | United States | 33.98444 | -81.87972 | 521 | 1877 |
| Owens | city | South Carolina | United States | 33.69333 | -79.38528 | 49 | 2594 |
| Owens | city | South Carolina | United States | 33.68972 | -78.90556 | 22 | 25853 |
| Owens Crossroad | city | South Carolina | United States | 33.15667 | -81.40111 | 213 | 743 |
| Owens historical | city | South Carolina | United States | 34.415 | -82.16833 | 613 | 3005 |
| Owings | city | South Carolina | United States | 34.63083 | -82.13361 | 820 | 3952 |
| Oxford | city | South Carolina | United States | 34.73611 | -82.94167 | 800 | 9913 |
| Oxford Acres | city | South Carolina | United States | 34.79944 | -82.45 | 898 | 73732 |
| Oyster Point | city | South Carolina | United States | 32.72194 | -79.92861 | 3 | 50215 |