| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Idlewild | city | South Carolina | United States | 34.73306 | -82.3625 | 902 | 19013 |
| Idlewood | city | South Carolina | United States | 34.23417 | -82.18972 | 649 | 19869 |
| Idlewood | city | South Carolina | United States | 33.92667 | -80.39861 | 170 | 38858 |
| Inabinetts historical | city | South Carolina | United States | 33.11028 | -80.34306 | 59 | 2357 |
| Independents | city | South Carolina | United States | 33.94444 | -80.90389 | 200 | 21196 |
| India Hook | city | South Carolina | United States | 35.00722 | -81.02194 | 636 | 23758 |
| Indian Hills | city | South Carolina | United States | 34.70694 | -82.92361 | 869 | 11783 |
| Indian Hills | city | South Carolina | United States | 34.52139 | -82.76056 | 751 | 10292 |
| Indian Hills subdivision | city | South Carolina | United States | 34.89139 | -82.45583 | 1003 | 67445 |
| Indian Oaks | city | South Carolina | United States | 34.71194 | -82.97778 | 787 | 9579 |
| Indian Pines | city | South Carolina | United States | 33.96417 | -81.17083 | 298 | 31605 |
| Indian Springs | city | South Carolina | United States | 32.98889 | -80.22889 | 52 | 27209 |
| Indian Trail | city | South Carolina | United States | 34.47556 | -82.70167 | 698 | 31649 |
| Indiantown | city | South Carolina | United States | 33.725 | -79.55972 | 39 | 1790 |
| Indigo Point subdivision | city | South Carolina | United States | 32.77861 | -80.00389 | 3 | 58099 |
| Indigo Run | city | South Carolina | United States | 32.20194 | -80.73056 | 3 | 17943 |
| Ingleside | city | South Carolina | United States | 35.14472 | -82.16833 | 912 | 7270 |
| Ingram Beach | city | South Carolina | United States | 33.81306 | -78.68667 | 0 | 9867 |
| Ingrams | city | South Carolina | United States | 34.46222 | -80.21 | 413 | 934 |
| Inlet Harbor | city | South Carolina | United States | 33.54167 | -79.02639 | 0 | 11206 |
| Inlet Oaks Village | city | South Carolina | United States | 33.52778 | -79.06639 | 9 | 3889 |
| Inman | city | South Carolina | United States | 35.04694 | -82.09028 | 944 | 11815 |
| Inman Mills | city | South Carolina | United States | 35.04139 | -82.10444 | 898 | 13918 |
| Irby | city | South Carolina | United States | 34.47778 | -82.01111 | 626 | 9937 |
| Irby historical | city | South Carolina | United States | 34.69306 | -79.82444 | 98 | 2081 |
| Iris | city | South Carolina | United States | 34.27417 | -82.40222 | 613 | 3020 |
| Iris Heights subdivision | city | South Carolina | United States | 33.92222 | -80.37278 | 147 | 42737 |
| Irmo | city | South Carolina | United States | 34.08583 | -81.18333 | 298 | 34505 |
| Iron Crossroads | city | South Carolina | United States | 32.87278 | -80.48889 | 29 | 1362 |
| Iron Gate | city | South Carolina | United States | 32.97694 | -80.17556 | 29 | 44884 |
| Irongate | city | South Carolina | United States | 32.46056 | -80.78556 | 26 | 13673 |
| Irvines Landing | city | South Carolina | United States | 34.23611 | -82.01056 | 498 | 4332 |
| Irving | city | South Carolina | United States | 34.26333 | -82.22639 | 610 | 8583 |
| Irwin | city | South Carolina | United States | 34.69361 | -80.8225 | 498 | 14998 |
| Isaqueena Park subdivision | city | South Carolina | United States | 34.86278 | -82.37333 | 925 | 94661 |
| Isaqueena Village subdivision | city | South Carolina | United States | 34.70611 | -82.79222 | 889 | 22022 |
| Isbell Heights subdivision | city | South Carolina | United States | 34.81917 | -82.34667 | 994 | 75340 |
| Iseman Crossroads | city | South Carolina | United States | 34.26861 | -79.95306 | 183 | 7374 |
| Isgett Circle | city | South Carolina | United States | 34.70139 | -79.93611 | 157 | 4835 |
| Island View Landing | city | South Carolina | United States | 35.02528 | -81.04333 | 597 | 20279 |
| Island of Palms | city | South Carolina | United States | 32.79 | -79.78444 | 0 | 7837 |
| Islandton | city | South Carolina | United States | 32.90889 | -80.93556 | 78 | 1351 |
| Islay historical | city | South Carolina | United States | 34.62389 | -79.7275 | 131 | 5750 |
| Isle of Palms | city | South Carolina | United States | 32.78667 | -79.795 | 0 | 16051 |
| Isle of Pines | city | South Carolina | United States | 34.33333 | -82.1025 | 492 | 5711 |
| Italy | city | South Carolina | United States | 33.44833 | -79.54111 | 26 | 3891 |
| Iva | city | South Carolina | United States | 34.30639 | -82.66389 | 777 | 3060 |
| Ivey Hall | city | South Carolina | United States | 33.89306 | -80.36528 | 144 | 38837 |
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