| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Eadytown | city | South Carolina | United States | 33.41222 | -80.14722 | 72 | 1884 |
| Eagle Crest | city | South Carolina | United States | 33.5625 | -79.04306 | 3 | 7169 |
| Eagle Point | city | South Carolina | United States | 33.51806 | -80.18722 | 49 | 2573 |
| Earle | city | South Carolina | United States | 33.46472 | -79.63639 | 29 | 1043 |
| Earle historical | city | South Carolina | United States | 33.6575 | -81.57 | 298 | 1704 |
| Earles Grove | city | South Carolina | United States | 34.56667 | -82.99194 | 807 | 3405 |
| Earlwood Park | city | South Carolina | United States | 34.32889 | -79.89167 | 173 | 15204 |
| Early Branch | city | South Carolina | United States | 32.74556 | -80.92806 | 68 | 1525 |
| Earlys Crossroads | city | South Carolina | United States | 34.30028 | -79.97417 | 187 | 4858 |
| Easley | city | South Carolina | United States | 34.82972 | -82.60167 | 1105 | 27574 |
| East Chester subdivision | city | South Carolina | United States | 33.70194 | -78.87222 | 0 | 18718 |
| East Gaffney | city | South Carolina | United States | 35.08 | -81.63306 | 787 | 12984 |
| East Gantt | city | South Carolina | United States | 34.76806 | -82.38472 | 951 | 44293 |
| East Gate Village | city | South Carolina | United States | 34.88722 | -82.29722 | 898 | 68165 |
| East Highland Estates subdivision | city | South Carolina | United States | 34.83667 | -82.35972 | 921 | 94661 |
| East Lake | city | South Carolina | United States | 34.10389 | -81.22667 | 400 | 24844 |
| East Lake Hills subdivision | city | South Carolina | United States | 34.07556 | -80.93611 | 252 | 57829 |
| East Shore | city | South Carolina | United States | 34.08972 | -81.23056 | 400 | 24844 |
| East Spartanburg | city | South Carolina | United States | 34.9325 | -81.89167 | 770 | 53656 |
| East Sumter | city | South Carolina | United States | 33.92528 | -80.29639 | 144 | 31547 |
| East Sunway Knolls subdivision | city | South Carolina | United States | 33.94861 | -80.38472 | 180 | 38858 |
| East View | city | South Carolina | United States | 34.63972 | -82.43722 | 797 | 12770 |
| East View Estates | city | South Carolina | United States | 34.14444 | -79.72528 | 78 | 24744 |
| Eastatoe | city | South Carolina | United States | 34.95194 | -82.90056 | 1000 | 1940 |
| Eastbriar subdivision | city | South Carolina | United States | 34.69972 | -82.79083 | 820 | 17216 |
| Eastcliff | city | South Carolina | United States | 34.77222 | -83.02056 | 826 | 9726 |
| Easterly Heights subdivision | city | South Carolina | United States | 35.11889 | -81.50278 | 715 | 6096 |
| Eastminster | city | South Carolina | United States | 34.65917 | -83.08444 | 898 | 5676 |
| Eastmont subdivision | city | South Carolina | United States | 33.96111 | -80.9225 | 229 | 51667 |
| Eastover | city | South Carolina | United States | 33.87667 | -80.69306 | 170 | 1755 |
| Eastway Park | city | South Carolina | United States | 33.93194 | -80.97222 | 134 | 41373 |
| Eau Claire | city | South Carolina | United States | 34.03444 | -81.04528 | 265 | 109410 |
| Ebenezer | city | South Carolina | United States | 34.78 | -83.00056 | 925 | 9726 |
| Ebenezer | city | South Carolina | United States | 34.95694 | -81.04667 | 669 | 44128 |
| Ebenezer | city | South Carolina | United States | 33.25583 | -80.325 | 82 | 2381 |
| Ebenezer | city | South Carolina | United States | 34.17583 | -79.85167 | 101 | 21756 |
| Eddy Lake historical | city | South Carolina | United States | 33.65 | -79.12083 | 19 | 2952 |
| Edens historical | city | South Carolina | United States | 34.60417 | -82.11111 | 698 | 3850 |
| Edenwood | city | South Carolina | United States | 33.95361 | -81.06 | 160 | 44235 |
| Edgefield | city | South Carolina | United States | 33.78944 | -81.92972 | 472 | 1552 |
| Edgefield Heights subdivision | city | South Carolina | United States | 33.50417 | -81.95639 | 403 | 41834 |
| Edgemere | city | South Carolina | United States | 34.22306 | -82.185 | 600 | 19869 |
| Edgemoor | city | South Carolina | United States | 34.80556 | -81.01167 | 538 | 3424 |
| Edgewater Park | city | South Carolina | United States | 32.77167 | -80.00167 | 3 | 58099 |
| Edgewater subdivision | city | South Carolina | United States | 33.92056 | -80.38139 | 154 | 38858 |
| Edgewood subdivision | city | South Carolina | United States | 34.28722 | -80.61389 | 278 | 7518 |
| Edinburgh | city | South Carolina | United States | 34.085 | -80.94861 | 259 | 42640 |
| Edisto | city | South Carolina | United States | 33.47639 | -80.89889 | 200 | 19296 |
| Edisto Beach | city | South Carolina | United States | 32.47917 | -80.335 | 3 | 202 |
| Edisto Club | city | South Carolina | United States | 33.40278 | -81.15639 | 180 | 2907 |
| Edisto Island | city | South Carolina | United States | 32.56 | -80.28 | 9 | 789 |
| Edistone historical | city | South Carolina | United States | 33.46806 | -80.88444 | 157 | 19296 |
| Edmund | city | South Carolina | United States | 33.86139 | -81.20028 | 413 | 6323 |
| Edwards | city | South Carolina | United States | 33.56417 | -79.955 | 68 | 1280 |
| Edwards Forest Heights | city | South Carolina | United States | 34.92639 | -82.31639 | 915 | 43065 |
| Effingham | city | South Carolina | United States | 34.05778 | -79.75333 | 98 | 5547 |
| Ehrhardt | city | South Carolina | United States | 33.09667 | -81.01444 | 150 | 975 |
| Eison Crossroads | city | South Carolina | United States | 34.46861 | -81.63639 | 498 | 1451 |
| Ekom | city | South Carolina | United States | 34.43139 | -82.14083 | 705 | 3038 |
| El Bethel | city | South Carolina | United States | 33.86389 | -79.09167 | 39 | 13639 |
| Elaine Heights subdivision | city | South Carolina | United States | 34.83583 | -82.5725 | 1043 | 20453 |
| Eleven Oaks | city | South Carolina | United States | 34.73333 | -82.98472 | 800 | 9579 |
| Elgin | city | South Carolina | United States | 34.17083 | -80.79444 | 305 | 6958 |
| Elgin | city | South Carolina | United States | 34.67278 | -80.71917 | 590 | 15161 |
| Elgin Acres | city | South Carolina | United States | 34.18528 | -80.78444 | 328 | 4645 |
| Elgin Farms | city | South Carolina | United States | 34.22222 | -80.82028 | 236 | 4411 |
| Elgin Woods | city | South Carolina | United States | 34.68417 | -80.70556 | 574 | 7417 |
| Elim | city | South Carolina | United States | 34.0475 | -79.79806 | 98 | 5786 |
| Elizabeth Heights | city | South Carolina | United States | 34.79556 | -82.44472 | 898 | 73732 |
| Elko | city | South Carolina | United States | 33.38028 | -81.37972 | 328 | 2693 |
| Ella | city | South Carolina | United States | 34.06417 | -81.42611 | 403 | 3491 |
| Ellenton historical | city | South Carolina | United States | 33.19861 | -81.75611 | 88 | 715 |
| Ellenwood Acres | city | South Carolina | United States | 34.16944 | -82.1875 | 600 | 24843 |
| Ellerbee historical | city | South Carolina | United States | 34.12861 | -80.55361 | 196 | 3134 |
| Ellerbee historical | city | South Carolina | United States | 34.10944 | -80.54722 | 187 | 2731 |
| Ellerbees Mill | city | South Carolina | United States | 34.06778 | -80.53194 | 147 | 4758 |
| Elleston Acres subdivision | city | South Carolina | United States | 34.85444 | -82.37306 | 898 | 94661 |
| Elliott | city | South Carolina | United States | 34.10694 | -80.16389 | 170 | 2842 |
| Ellis historical | city | South Carolina | United States | 34.13278 | -81.77306 | 498 | 987 |
| Elloree | city | South Carolina | United States | 33.53083 | -80.57222 | 167 | 2393 |
| Ellwood | city | South Carolina | United States | 33.11083 | -79.93639 | 39 | 1857 |
| Elm Abode | city | South Carolina | United States | 34.03167 | -81.08194 | 282 | 109410 |
| Elmwood Park | city | South Carolina | United States | 33.50417 | -81.70333 | 449 | 22953 |
| Elmwood subdivision | city | South Carolina | United States | 34.01333 | -81.04694 | 298 | 109410 |
| Elsie | city | South Carolina | United States | 33.93194 | -81.33417 | 531 | 4391 |
| Embree | city | South Carolina | United States | 33.25778 | -80.89222 | 111 | 1825 |
| Emerald Place | city | South Carolina | United States | 34.20806 | -82.11417 | 511 | 15996 |
| Emerald Valley | city | South Carolina | United States | 34.045 | -81.08472 | 209 | 66219 |
| Emory | city | South Carolina | United States | 33.98722 | -81.70361 | 446 | 2091 |
| Enchanted Forest | city | South Carolina | United States | 34.87167 | -82.46222 | 997 | 48790 |
| Enchanted Hills | city | South Carolina | United States | 34.70694 | -82.91056 | 800 | 15633 |
| Enchanted Meadows | city | South Carolina | United States | 34.15917 | -79.80389 | 118 | 32256 |
| Englewood | city | South Carolina | United States | 34.55639 | -82.62639 | 800 | 27558 |
| English Crossroads | city | South Carolina | United States | 34.11556 | -80.2225 | 170 | 2574 |
| English Gardens subdivision | city | South Carolina | United States | 35.00694 | -81.21833 | 685 | 11658 |
| English historical | city | South Carolina | United States | 34.07778 | -80.69472 | 255 | 3946 |
| Enola | city | South Carolina | United States | 35.01528 | -81.86778 | 803 | 19509 |
| Enoree | city | South Carolina | United States | 34.65639 | -81.96528 | 600 | 4509 |
| Enoree Hills | city | South Carolina | United States | 34.90639 | -82.28194 | 862 | 50657 |
| Enos | city | South Carolina | United States | 33.79722 | -81.04639 | 203 | 5616 |
| Ensenaka historical | city | South Carolina | United States | 34.68 | -82.855 | 688 | 21105 |
| Enterprise Landing | city | South Carolina | United States | 33.66889 | -79.06083 | 19 | 6651 |
| Epworth | city | South Carolina | United States | 34.08861 | -82.04222 | 551 | 3477 |
| Erie historical | city | South Carolina | United States | 34.47222 | -82.27083 | 705 | 2946 |
| Erskine Estates | city | South Carolina | United States | 34.50278 | -82.57278 | 685 | 13194 |
| Erwin | city | South Carolina | United States | 34.69167 | -80.81528 | 498 | 14998 |
| Erwin Park | city | South Carolina | United States | 34.34 | -80.0475 | 203 | 14769 |
| Erwinwood Acres subdivision | city | South Carolina | United States | 34.69028 | -80.80472 | 501 | 14998 |
| Essex Village subdivision | city | South Carolina | United States | 32.795 | -80.04306 | 9 | 49451 |
| Estill | city | South Carolina | United States | 32.75472 | -81.24222 | 104 | 1483 |
| Ethon Crossroads | city | South Carolina | United States | 33.93111 | -81.31306 | 449 | 6733 |
| Etta historical | city | South Carolina | United States | 34.92917 | -81.49028 | 508 | 2557 |
| Eulala | city | South Carolina | United States | 34.03056 | -81.91944 | 531 | 1771 |
| Eulonia | city | South Carolina | United States | 33.98639 | -79.38361 | 39 | 926 |
| Eureka | city | South Carolina | United States | 33.69389 | -81.76722 | 498 | 3940 |
| Eureka Mill | city | South Carolina | United States | 34.7175 | -81.19389 | 498 | 11187 |
| Eureka Mills | city | South Carolina | United States | 34.71806 | -81.19722 | 515 | 11187 |
| Eutaw Springs | city | South Carolina | United States | 33.40667 | -80.30111 | 91 | 3110 |
| Eutawville | city | South Carolina | United States | 33.39444 | -80.3475 | 114 | 3112 |
| Evans | city | South Carolina | United States | 34.66972 | -81.19083 | 600 | 11126 |
| Evans Acres | city | South Carolina | United States | 34.90472 | -81.95611 | 695 | 43266 |
| Evans Crossroads | city | South Carolina | United States | 33.96389 | -79.51444 | 59 | 1952 |
| Evans Mill | city | South Carolina | United States | 34.72667 | -80.35028 | 472 | 3009 |
| Evanston Estates subdivision | city | South Carolina | United States | 32.85667 | -80.04944 | 3 | 55687 |
| Everetts historical | city | South Carolina | United States | 34.67278 | -79.78889 | 144 | 3089 |
| Evergreen | city | South Carolina | United States | 32.98 | -80.19611 | 29 | 44884 |
| Evergreen | city | South Carolina | United States | 34.06833 | -79.67917 | 88 | 3892 |
| Evergreen Acres | city | South Carolina | United States | 34.72833 | -80.70278 | 587 | 7869 |
| Evergreen Hills | city | South Carolina | United States | 34.51944 | -82.68639 | 702 | 35636 |
| Evergreen Park | city | South Carolina | United States | 34.08278 | -81.04306 | 193 | 80809 |
| Evinsville | city | South Carolina | United States | 34.68361 | -81.88806 | 695 | 2679 |
| Excelsior historical | city | South Carolina | United States | 34.69583 | -79.93194 | 177 | 4835 |
| Ezell historical | city | South Carolina | United States | 35.13778 | -81.81694 | 984 | 5128 |