| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Sibley | city | Missouri | United States | 39.17861 | -94.19306 | 800 | 3056 |
| Sidney | city | Missouri | United States | 40.35417 | -92.81889 | 977 | 333 |
| Signal historical | city | Missouri | United States | 38.03111 | -91.81528 | 892 | 3516 |
| Sigsbee | city | Missouri | United States | 39.9075 | -91.86861 | 705 | 461 |
| Sikeston | city | Missouri | United States | 36.87667 | -89.58778 | 328 | 17025 |
| Silex | city | Missouri | United States | 39.12333 | -91.05417 | 508 | 1259 |
| Silica | city | Missouri | United States | 38.23472 | -90.42583 | 403 | 19683 |
| Siloam Springs | city | Missouri | United States | 40.37306 | -94.26389 | 921 | 501 |
| Siloam Springs | city | Missouri | United States | 36.79556 | -92.07528 | 997 | 776 |
| Silva | city | Missouri | United States | 37.17611 | -90.46361 | 419 | 634 |
| Silver Creek | city | Missouri | United States | 37.04056 | -94.4725 | 1062 | 23857 |
| Silver Dollar City | city | Missouri | United States | 36.66778 | -93.33944 | 1204 | 4041 |
| Silver Lake | city | Missouri | United States | 37.68361 | -89.99 | 587 | 1167 |
| Silver Springs | city | Missouri | United States | 37.99917 | -90.52444 | 895 | 5592 |
| Silverleaf | city | Missouri | United States | 39.90472 | -93.61583 | 770 | 477 |
| Silverton | city | Missouri | United States | 36.81722 | -92.56528 | 1095 | 587 |
| Simcoe | city | Missouri | United States | 36.72167 | -94.16722 | 1282 | 909 |
| Simler | city | Missouri | United States | 40.1225 | -92.69528 | 800 | 727 |
| Simmons | city | Missouri | United States | 37.23056 | -92.01528 | 1099 | 944 |
| Simpson | city | Missouri | United States | 39.08333 | -93.74972 | 800 | 2495 |
| Simpson | city | Missouri | United States | 36.66056 | -91.37361 | 718 | 427 |
| Sims Point | city | Missouri | United States | 37.47556 | -93.955 | 997 | 595 |
| Sims historical | city | Missouri | United States | 36.54583 | -90.50778 | 295 | 1104 |
| Sinkin historical | city | Missouri | United States | 37.40944 | -91.40611 | 1000 | 295 |
| Sinsabaugh | city | Missouri | United States | 36.50444 | -90.70194 | 278 | 1161 |
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