| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
| Shackleford | city | Missouri | United States | 39.1125 | -93.29667 | 800 | 750 |
| Shackleford Crossing | city | Missouri | United States | 38.89194 | -93.03333 | 610 | 686 |
| Shade | city | Missouri | United States | 36.17556 | -89.76667 | 259 | 4474 |
| Shady Dell | city | Missouri | United States | 36.76778 | -90.44194 | 396 | 16852 |
| Shady Dell | city | Missouri | United States | 36.96389 | -89.8225 | 308 | 1165 |
| Shady Grove | city | Missouri | United States | 36.97472 | -93.13556 | 1295 | 3286 |
| Shady Grove | city | Missouri | United States | 37.50944 | -92.87972 | 1299 | 1212 |
| Shady Grove | city | Missouri | United States | 37.85861 | -92.27778 | 898 | 3293 |
| Shafter | city | Missouri | United States | 39.98389 | -93.28472 | 803 | 453 |
| Shamrock | city | Missouri | United States | 39.00278 | -91.69417 | 744 | 826 |
| Shannondale | city | Missouri | United States | 39.35917 | -92.84972 | 646 | 844 |
| Shannondale | city | Missouri | United States | 37.39 | -91.4375 | 1000 | 295 |
| Shantytown | city | Missouri | United States | 38.03389 | -92.04583 | 997 | 1033 |
| Sharon | city | Missouri | United States | 39.30056 | -93.13306 | 705 | 574 |
| Sharp | city | Missouri | United States | 36.60028 | -92.2075 | 898 | 565 |
| Sharpsburg | city | Missouri | United States | 39.68694 | -91.76222 | 715 | 589 |
| Shaver Ford | city | Missouri | United States | 39.52167 | -91.68944 | 551 | 508 |
| Shaw | city | Missouri | United States | 38.97361 | -92.20306 | 875 | 4966 |
| Shawan | city | Missouri | United States | 36.96389 | -89.77972 | 305 | 1209 |
| Shawne | city | Missouri | United States | 37.12139 | -91.26028 | 898 | 290 |
| Shawnee Mound | city | Missouri | United States | 38.52972 | -93.76167 | 948 | 577 |
| Shawneetown | city | Missouri | United States | 37.55111 | -89.65194 | 475 | 1096 |
| Sheil | city | Missouri | United States | 39.63389 | -91.59833 | 626 | 503 |
| Shelbina | city | Missouri | United States | 39.69389 | -92.04278 | 754 | 1041 |
| Shelby | city | Missouri | United States | 39.96861 | -93.01806 | 898 | 367 |
| Shelby | city | Missouri | United States | 36.50361 | -91.52222 | 692 | 919 |
| Shelbyville | city | Missouri | United States | 39.80583 | -92.04139 | 751 | 541 |
| Sheldon | city | Missouri | United States | 37.65806 | -94.2925 | 902 | 557 |
| Shell Knob | city | Missouri | United States | 36.63222 | -93.63417 | 1187 | 945 |
| Shelton Ford | city | Missouri | United States | 37.35139 | -90.47917 | 485 | 468 |
| Shepard historical | city | Missouri | United States | 37.69639 | -90.88694 | 1305 | 584 |
| Sheridan | city | Missouri | United States | 40.51806 | -94.61194 | 1033 | 476 |
| Sherman | city | Missouri | United States | 38.53778 | -90.59194 | 449 | 25151 |
| Sherrill | city | Missouri | United States | 37.58861 | -91.87611 | 1145 | 672 |
| Sherwood historical | city | Missouri | United States | 37.4275 | -94.17722 | 1017 | 1017 |
| Shibboleth | city | Missouri | United States | 38.00556 | -90.70528 | 816 | 2246 |
| Shibleys Point | city | Missouri | United States | 40.31333 | -92.76083 | 839 | 414 |
| Shirley | city | Missouri | United States | 37.915 | -90.91917 | 997 | 653 |
| Shoal | city | Missouri | United States | 39.65306 | -93.93278 | 761 | 759 |
| Shoal Creek Drive | city | Missouri | United States | 37.04083 | -94.51917 | 997 | 27659 |
| Shoal Creek Estates | city | Missouri | United States | 37.01806 | -94.495 | 921 | 23857 |
| Shook | city | Missouri | United States | 37.04278 | -90.30889 | 442 | 547 |
| Short Bend | city | Missouri | United States | 37.74639 | -91.43389 | 948 | 462 |
| Shott | city | Missouri | United States | 40.16222 | -93.66056 | 833 | 2044 |
| Shoveltown | city | Missouri | United States | 38.81556 | -90.28056 | 498 | 104618 |
| Shover historical | city | Missouri | United States | 36.69 | -90.09583 | 321 | 1461 |
| Shreve | city | Missouri | United States | 36.64611 | -90.09583 | 321 | 1571 |
| Shrewsbury | city | Missouri | United States | 38.59028 | -90.33667 | 511 | 179519 |
| Shrum | city | Missouri | United States | 37.38389 | -90.015 | 583 | 957 |
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