| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Sabernawau Village | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.3333333 | -59.2333333 | 941 | 47 |
| Saint Bede's Mission | city | Barima-Waini Region | Guyana | 7.5666667 | -59.4666667 | 95 | 168 |
| Saint Bedes | city | Barima-Waini Region | Guyana | 7.5666667 | -59.4666667 | 95 | 168 |
| Saint Bedeʼs Mission | city | Barima-Waini Region | Guyana | 7.5666667 | -59.4666667 | 95 | 168 |
| Saint Benedict Mission | city | Barima-Waini Region | Guyana | 7.8166667 | -59.8333333 | 223 | 168 |
| Saint Cuthberts | city | Mahaica-Berbice Region | Guyana | 6.3666667 | -58.0833333 | 75 | 9587 |
| Saint Cuthberts Mission | city | Mahaica-Berbice Region | Guyana | 6.3666667 | -58.0833333 | 75 | 9587 |
| Saint Cuthberts Village | city | Mahaica-Berbice Region | Guyana | 6.3666667 | -58.0833333 | 75 | 9587 |
| Saint Edwards Mission | city | Cuyuni-Mazaruni Region | Guyana | 6.3666667 | -58.7 | 6 | 47 |
| Saint Francis Mission | city | Mahaica-Berbice Region | Guyana | 6.1 | -57.95 | 82 | 2371 |
| Saint Ignatius | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.3333333 | -59.8 | 334 | 73 |
| Saint Ignatius Mission | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.3333333 | -59.8 | 334 | 73 |
| Saint John | city | Mahaica-Berbice Region | Guyana | 6.3833333 | -57.6166667 | 3 | 1398 |
| Saint Mary | city | Potaro-Siparuni Region | Guyana | 5.2 | -59.0166667 | 1551 | 42 |
| Saint Mary's | city | Potaro-Siparuni Region | Guyana | 5.2 | -59.0166667 | 1551 | 42 |
| Saint Marys | city | Cuyuni-Mazaruni Region | Guyana | 6.25 | -58.5833333 | 13 | 308 |
| Saint Maryʼs | city | Potaro-Siparuni Region | Guyana | 5.2 | -59.0166667 | 1551 | 42 |
| Saint Nicholas | city | Pomeroon-Supenaam Region | Guyana | 7.5 | -58.95 | 141 | 1237 |
| Saint Nicholas Mission | city | Pomeroon-Supenaam Region | Guyana | 7.5 | -58.95 | 141 | 1237 |
| Sand Creek Village | city | Upper Takutu-Upper Essequibo Region | Guyana | 3 | -59.5166667 | 492 | 47 |
| Sand Hills | city | Upper Demerara-Berbice Region | Guyana | 5.8 | -57.75 | 62 | 400 |
| Santa Cruz | city | Barima-Waini Region | Guyana | 7.65 | -59.2333333 | 98 | 168 |
| Santa Fe | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.7833333 | -59.6 | 298 | 77 |
| Santa Fe Ranch | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.7833333 | -59.6 | 298 | 77 |
| Santa Fé Ranch | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.7833333 | -59.6 | 298 | 77 |
| Santa Rosa | city | Barima-Waini Region | Guyana | 7.65 | -58.95 | 68 | 241 |
| Santa Rosa Mission | city | Barima-Waini Region | Guyana | 7.65 | -58.95 | 68 | 241 |
| Sarah | city | Essequibo Islands-West Demerara Region | Guyana | 6.9666667 | -58.4666667 | 3 | 2308 |
| Sawariwau | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.6833333 | -59.65 | 652 | 47 |
| Sawariwaunawa | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.6833333 | -59.65 | 652 | 47 |
| Saxacalli | city | Essequibo Islands-West Demerara Region | Guyana | 6.5833333 | -58.6166667 | 3 | 3053 |
| Saxakalli | city | Essequibo Islands-West Demerara Region | Guyana | 6.5833333 | -58.6166667 | 3 | 3053 |
| Saxsacali | city | Essequibo Islands-West Demerara Region | Guyana | 6.5833333 | -58.6166667 | 3 | 3053 |
| Scottsburg | city | East Berbice-Corentyne Region | Guyana | 5.9166667 | -57.1333333 | 0 | 448 |
| Shea | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.8166667 | -59.1333333 | 1017 | 47 |
| Shea Village | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.8166667 | -59.1333333 | 1017 | 47 |
| Shoa | city | Upper Takutu-Upper Essequibo Region | Guyana | 2.8166667 | -59.1333333 | 1017 | 47 |
| Shulinab | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.0833333 | -59.7833333 | 488 | 47 |
| Shulinab Village | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.0833333 | -59.7833333 | 488 | 47 |
| Simiri | city | Pomeroon-Supenaam Region | Guyana | 7.2166667 | -58.6666667 | 55 | 1237 |
| Simirie | city | Essequibo Islands-West Demerara Region | Guyana | 6.5166667 | -58.5833333 | 3 | 3036 |
| Sinclair Landing | city | Barima-Waini Region | Guyana | 7.7666667 | -59.8333333 | 364 | 168 |
| Sinking Ground | city | Mahaica-Berbice Region | Guyana | 6.3333333 | -57.8833333 | 6 | 2371 |
| Sion | city | Upper Demerara-Berbice Region | Guyana | 5.6833333 | -57.85 | 75 | 397 |
| Sir James | city | Mahaica-Berbice Region | Guyana | 6.2833333 | -57.5333333 | 3 | 1265 |
| Sirikie | city | Pomeroon-Supenaam Region | Guyana | 7.3 | -58.6666667 | 78 | 1237 |
| Sisipelin | city | Potaro-Siparuni Region | Guyana | 4.65 | -59.55 | 2916 | 42 |
| Sisipelin Village | city | Potaro-Siparuni Region | Guyana | 4.65 | -59.55 | 2916 | 42 |
| Skeldon | city | East Berbice-Corentyne Region | Guyana | 5.8833333 | -57.1333333 | 0 | 513 |
| Skeldon Place | city | East Berbice-Corentyne Region | Guyana | 5.8833333 | -57.1333333 | 0 | 513 |
| Smythfield | city | East Berbice-Corentyne Region | Guyana | 6.2333333 | -57.5166667 | 3 | 1265 |
| Soesdyk | city | Essequibo Islands-West Demerara Region | Guyana | 6.5333333 | -58.25 | 3 | 22093 |
| Soesdyke | city | Essequibo Islands-West Demerara Region | Guyana | 6.5333333 | -58.25 | 3 | 22093 |
| Somerset | city | Pomeroon-Supenaam Region | Guyana | 7.4 | -58.5666667 | 13 | 1044 |
| Springlands | city | East Berbice-Corentyne Region | Guyana | 5.9 | -57.15 | 3 | 513 |
| Springlands Place | city | East Berbice-Corentyne Region | Guyana | 5.9 | -57.15 | 3 | 513 |
| Stabroek | city | Demerara-Mahaica Region | Guyana | 6.8166667 | -58.15 | 3 | 13391 |
| Stanleytown | city | Essequibo Islands-West Demerara Region | Guyana | 6.7333333 | -58.2 | 3 | 14912 |
| Stanleytown | city | East Berbice-Corentyne Region | Guyana | 6.2333333 | -57.5166667 | 3 | 1265 |
| Subryanville | city | Demerara-Mahaica Region | Guyana | 6.8333333 | -58.1333333 | 0 | 13391 |
| Suddie | city | Pomeroon-Supenaam Region | Guyana | 7.1166667 | -58.4833333 | 3 | 975 |
| Sunnyside | city | Upper Takutu-Upper Essequibo Region | Guyana | 3.7 | -59.65 | 331 | 66 |
| Surama | city | Upper Takutu-Upper Essequibo Region | Guyana | 4.1666667 | -59.0833333 | 590 | 46 |
| Surama Village | city | Upper Takutu-Upper Essequibo Region | Guyana | 4.1666667 | -59.0833333 | 590 | 46 |
| Surprise Hill | city | Barima-Waini Region | Guyana | 7.8166667 | -59.8 | 291 | 168 |
| Surumatra | city | Upper Takutu-Upper Essequibo Region | Guyana | 4.1666667 | -59.0666667 | 528 | 46 |