| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| SYCJ (CHEDDI JAGAN INTL) | airport | Guyana | 6.50 | -58.25 | 95 | 0 | |
| SYLD (LINDEN) | airport | Guyana | 5.97 | -58.27 | 180 | 0 | |
| SYLT (LETHEM) | airport | Guyana | 3.37 | -59.79 | 351 | 0 | |
| Sabernawau Village | city | Upper Takutu-Upper Essequibo | Guyana | 2.33 | -59.23 | 941 | 0 |
| Saint Bede's Mission | city | Barima-Waini | Guyana | 7.57 | -59.47 | 95 | 149 |
| Saint Bedes | city | Barima-Waini | Guyana | 7.57 | -59.47 | 95 | 149 |
| Saint Bede’s Mission | city | Barima-Waini | Guyana | 7.57 | -59.47 | 95 | 149 |
| Saint Benedict Mission | city | Barima-Waini | Guyana | 7.82 | -59.83 | 223 | 149 |
| Saint Cuthberts | city | Demerara-Mahaica | Guyana | 6.37 | -58.09 | 75 | 14518 |
| Saint Cuthberts Mission | city | Demerara-Mahaica | Guyana | 6.37 | -58.09 | 75 | 14518 |
| Saint Cuthberts Village | city | Demerara-Mahaica | Guyana | 6.37 | -58.09 | 75 | 14518 |
| Saint Edwards Mission | city | Cuyuni-Mazaruni | Guyana | 6.37 | -58.70 | 3 | 695 |
| Saint Francis Mission | city | Mahaica-Berbice | Guyana | 6.10 | -57.95 | 82 | 1043 |
| Saint Ignatius | city | Upper Takutu-Upper Essequibo | Guyana | 3.33 | -59.80 | 334 | 271 |
| Saint Ignatius Mission | city | Upper Takutu-Upper Essequibo | Guyana | 3.33 | -59.80 | 334 | 271 |
| Saint Jan | city | Essequibo Islands-West Demerara | Guyana | 6.28 | -58.28 | 88 | 298 |
| Saint John | city | Mahaica-Berbice | Guyana | 6.39 | -57.62 | 3 | 766 |
| Saint Mary | city | Potaro-Siparuni | Guyana | 5.20 | -59.02 | 1669 | 0 |
| Saint Mary's | city | Potaro-Siparuni | Guyana | 5.20 | -59.02 | 1669 | 0 |
| Saint Marys | city | Cuyuni-Mazaruni | Guyana | 6.24 | -58.58 | 13 | 0 |
| Saint Mary’s | city | Potaro-Siparuni | Guyana | 5.20 | -59.02 | 1669 | 0 |
| Saint Monica | city | Pomeroon-Supenaam | Guyana | 7.24 | -58.78 | 183 | 894 |
| Saint Monica Mission | city | Pomeroon-Supenaam | Guyana | 7.24 | -58.78 | 183 | 894 |
| Saint Nicholas | city | Pomeroon-Supenaam | Guyana | 7.50 | -58.95 | 141 | 894 |
| Saint Nicholas Mission | city | Pomeroon-Supenaam | Guyana | 7.50 | -58.95 | 141 | 894 |
| San Victor | city | Barima-Waini | Guyana | 7.98 | -60.17 | 229 | 98 |
| Sand Creek Village | city | Upper Takutu-Upper Essequibo | Guyana | 3.00 | -59.52 | 830 | 0 |
| Sand Hills | city | Upper Demerara-Berbice | Guyana | 5.81 | -57.74 | 62 | 745 |
| Sand Hills | city | Upper Demerara-Berbice | Guyana | 5.80 | -57.75 | 62 | 745 |
| Sand Hills | city | Essequibo Islands-West Demerara | Guyana | 6.48 | -58.31 | 22 | 298 |
| Sandhills | city | Upper Demerara-Berbice | Guyana | 5.81 | -57.74 | 62 | 745 |
| Sands | city | Cuyuni-Mazaruni | Guyana | 6.10 | -59.96 | 242 | 0 |
| Sans Souci | city | Demerara-Mahaica | Guyana | 6.44 | -58.29 | 26 | 298 |
| Sant Hoek Point | city | Cuyuni-Mazaruni | Guyana | 6.35 | -58.70 | 6 | 5 |
| Santa Cruz | city | Barima-Waini | Guyana | 7.65 | -59.23 | 98 | 149 |
| Santa Fe | city | Upper Takutu-Upper Essequibo | Guyana | 3.78 | -59.60 | 298 | 31 |
| Santa Fe Ranch | city | Upper Takutu-Upper Essequibo | Guyana | 3.78 | -59.60 | 298 | 31 |
| Santa Mission | city | Essequibo Islands-West Demerara | Guyana | 6.56 | -58.33 | 16 | 298 |
| Santa Rosa | city | Barima-Waini | Guyana | 7.65 | -58.95 | 68 | 151 |
| Santa Rosa Mission | city | Barima-Waini | Guyana | 7.65 | -58.95 | 68 | 151 |
| Sarah | city | Essequibo Islands-West Demerara | Guyana | 6.97 | -58.46 | 3 | 139 |
| Sarah Johanna | city | Demerara-Mahaica | Guyana | 6.59 | -58.21 | 6 | 527 |
| Sawariwau | city | Upper Takutu-Upper Essequibo | Guyana | 2.68 | -59.65 | 830 | 0 |
| Sawariwaunawa | city | Upper Takutu-Upper Essequibo | Guyana | 2.68 | -59.65 | 830 | 0 |
| Saxacalli | city | Essequibo Islands-West Demerara | Guyana | 6.58 | -58.61 | 0 | 181 |
| Saxakalli | city | Essequibo Islands-West Demerara | Guyana | 6.58 | -58.61 | 0 | 181 |
| Saxsacali | city | Essequibo Islands-West Demerara | Guyana | 6.58 | -58.61 | 0 | 181 |
| Scherners Vergenoegen | city | Upper Demerara-Berbice | Guyana | 5.79 | -57.74 | 59 | 745 |
| Schoonoord | city | Essequibo Islands-West Demerara | Guyana | 6.78 | -58.20 | 3 | 36010 |
| Schoonord | city | Essequibo Islands-West Demerara | Guyana | 6.78 | -58.20 | 3 | 36010 |
| Scottsburg | city | East Berbice-Corentyne | Guyana | 5.91 | -57.14 | 0 | 782 |
| Seafield | city | Mahaica-Berbice | Guyana | 6.48 | -57.67 | 3 | 633 |
| Second Point | city | Mahaica-Berbice | Guyana | 6.47 | -57.73 | 3 | 1022 |
| Shea | city | Upper Takutu-Upper Essequibo | Guyana | 2.82 | -59.13 | 1017 | 0 |
| Shea Village | city | Upper Takutu-Upper Essequibo | Guyana | 2.82 | -59.13 | 1017 | 0 |
| Shebedia | city | Demerara-Mahaica | Guyana | 6.36 | -58.09 | 78 | 13444 |
| Shoa | city | Upper Takutu-Upper Essequibo | Guyana | 2.82 | -59.13 | 1017 | 0 |
| Shulinab | city | Upper Takutu-Upper Essequibo | Guyana | 3.08 | -59.78 | 830 | 0 |
| Shulinab Village | city | Upper Takutu-Upper Essequibo | Guyana | 3.08 | -59.78 | 830 | 0 |
| Simari | city | Mahaica-Berbice | Guyana | 6.41 | -58.04 | 45 | 10978 |
| Simeri | city | Mahaica-Berbice | Guyana | 6.41 | -58.04 | 45 | 10978 |
| Simiri | city | Pomeroon-Supenaam | Guyana | 7.22 | -58.67 | 55 | 894 |
| Simiri | city | Mahaica-Berbice | Guyana | 6.41 | -58.04 | 45 | 10978 |
| Simirie | city | Essequibo Islands-West Demerara | Guyana | 6.52 | -58.58 | 3 | 132 |
| Sinclair Landing | city | Barima-Waini | Guyana | 7.77 | -59.83 | 337 | 149 |
| Sinking Ground | city | Mahaica-Berbice | Guyana | 6.34 | -57.87 | 6 | 1043 |
| Sion | city | Upper Demerara-Berbice | Guyana | 5.68 | -57.85 | 75 | 745 |
| Sir James | city | Mahaica-Berbice | Guyana | 6.28 | -57.53 | 3 | 17541 |
| Sirikie | city | Pomeroon-Supenaam | Guyana | 7.30 | -58.67 | 78 | 894 |
| Sisipelin | city | Potaro-Siparuni | Guyana | 4.65 | -59.55 | 2916 | 0 |
| Sisipelin Village | city | Potaro-Siparuni | Guyana | 4.65 | -59.55 | 2916 | 0 |
| Skeldon | city | East Berbice-Corentyne | Guyana | 5.88 | -57.13 | 0 | 836 |
| Skeldon Place | city | East Berbice-Corentyne | Guyana | 5.88 | -57.13 | 0 | 836 |
| Slingeland | city | Upper Demerara-Berbice | Guyana | 5.77 | -57.74 | 59 | 745 |
| Slingleland | city | Upper Demerara-Berbice | Guyana | 5.77 | -57.74 | 59 | 745 |
| Smythfield | city | East Berbice-Corentyne | Guyana | 6.25 | -57.51 | 3 | 27842 |
| Soesdyke | city | Essequibo Islands-West Demerara | Guyana | 6.54 | -58.20 | 16 | 298 |
| Solitude | city | Upper Demerara-Berbice | Guyana | 5.77 | -57.74 | 59 | 745 |
| Somerset | city | Pomeroon-Supenaam | Guyana | 7.40 | -58.57 | 13 | 790 |
| South Ruimveldt Gardens | city | Demerara-Mahaica | Guyana | 6.79 | -58.14 | 3 | 43289 |
| South Ruimveldt Park | city | Demerara-Mahaica | Guyana | 6.79 | -58.14 | 3 | 42109 |
| Spring Garden | city | East Berbice-Corentyne | Guyana | 5.91 | -57.16 | 3 | 891 |
| Spring Garden | city | Essequibo Islands-West Demerara | Guyana | 6.30 | -58.27 | 78 | 298 |
| Springlands | city | East Berbice-Corentyne | Guyana | 5.90 | -57.13 | 0 | 801 |
| Springlands Place | city | East Berbice-Corentyne | Guyana | 5.90 | -57.13 | 0 | 801 |
| Stabroek | city | Demerara-Mahaica | Guyana | 6.81 | -58.16 | 3 | 33036 |
| Stanleytown | city | East Berbice-Corentyne | Guyana | 6.23 | -57.51 | 3 | 28107 |
| Stanleytown | city | Essequibo Islands-West Demerara | Guyana | 6.73 | -58.21 | 3 | 36678 |
| Stena | city | Essequibo Islands-West Demerara | Guyana | 6.38 | -58.31 | 59 | 298 |
| Stockholm | city | East Berbice-Corentyne | Guyana | 5.92 | -57.15 | 3 | 848 |
| Stop Off | city | Demerara-Mahaica | Guyana | 6.53 | -58.02 | 9 | 23244 |
| Subryanville | city | Demerara-Mahaica | Guyana | 6.83 | -58.14 | 3 | 21890 |
| Success | city | Demerara-Mahaica | Guyana | 6.81 | -58.09 | 3 | 29357 |
| Suddie | city | Pomeroon-Supenaam | Guyana | 7.11 | -58.48 | 3 | 535 |
| Sunnyside | city | Upper Takutu-Upper Essequibo | Guyana | 3.70 | -59.65 | 331 | 24 |
| Surama | city | Upper Takutu-Upper Essequibo | Guyana | 4.17 | -59.08 | 830 | 0 |
| Surama Village | city | Upper Takutu-Upper Essequibo | Guyana | 4.17 | -59.08 | 830 | 0 |
| Surprise Hill | city | Barima-Waini | Guyana | 7.82 | -59.80 | 291 | 149 |
| Surumatra | city | Upper Takutu-Upper Essequibo | Guyana | 4.17 | -59.07 | 830 | 0 |
| Susannahs Rust | city | Demerara-Mahaica | Guyana | 6.36 | -58.31 | 55 | 298 |
| Swart Hoek | city | Essequibo Islands-West Demerara | Guyana | 6.52 | -58.61 | 0 | 109 |
| Swarte Hoek | city | Essequibo Islands-West Demerara | Guyana | 6.52 | -58.61 | 0 | 109 |