| Name | What | Region | Country | Lat | Long | Elev ft. | Pop est |
|---|---|---|---|---|---|---|---|
| East La Penitence | city | Demerara-Mahaica | Guyana | 6.80 | -58.15 | 3 | 40509 |
| East Ruimveldt | city | Demerara-Mahaica | Guyana | 6.79 | -58.15 | 3 | 40509 |
| Ebini | city | Upper Demerara-Berbice | Guyana | 5.67 | -57.78 | 75 | 745 |
| Ebini Downs | city | Upper Demerara-Berbice | Guyana | 5.67 | -57.78 | 75 | 745 |
| Eendragt | city | Upper Demerara-Berbice | Guyana | 5.77 | -57.71 | 59 | 745 |
| Ekereku | city | Cuyuni-Mazaruni | Guyana | 6.47 | -60.83 | 980 | 0 |
| Ekishish-Suba | city | Upper Takutu-Upper Essequibo | Guyana | 2.50 | -59.90 | 830 | 38 |
| Eldorado | city | Mahaica-Berbice | Guyana | 6.51 | -57.70 | 3 | 563 |
| Eldorado Village | city | Mahaica-Berbice | Guyana | 6.51 | -57.70 | 3 | 563 |
| Eliza and Mary | city | East Berbice-Corentyne | Guyana | 5.90 | -57.15 | 3 | 842 |
| Elizabeth | city | Essequibo Islands-West Demerara | Guyana | 6.92 | -58.43 | 3 | 143 |
| Elizabeth Ann | city | Demerara-Mahaica | Guyana | 6.45 | -58.30 | 22 | 298 |
| Enachu | city | Cuyuni-Mazaruni | Guyana | 6.15 | -60.03 | 275 | 0 |
| Enachu Landing | city | Cuyuni-Mazaruni | Guyana | 6.15 | -60.03 | 275 | 0 |
| Enachu Station | city | Cuyuni-Mazaruni | Guyana | 6.15 | -60.03 | 275 | 0 |
| Enaruko Village | city | Potaro-Siparuni | Guyana | 4.57 | -59.67 | 2509 | 0 |
| Enmore | city | Demerara-Mahaica | Guyana | 6.77 | -57.98 | 3 | 78567 |
| Enterprise | city | Essequibo Islands-West Demerara | Guyana | 6.92 | -58.40 | 0 | 134 |
| Epira | city | East Berbice-Corentyne | Guyana | 5.13 | -57.33 | 75 | 281 |
| Epira Mission | city | East Berbice-Corentyne | Guyana | 5.13 | -57.33 | 75 | 281 |
| Esau and Jacob | city | Mahaica-Berbice | Guyana | 6.48 | -57.79 | 3 | 2018 |
| Espera | city | East Berbice-Corentyne | Guyana | 5.13 | -57.33 | 75 | 281 |
| Essau and Jacob | city | Mahaica-Berbice | Guyana | 6.48 | -57.79 | 3 | 2018 |
| Essekwabo | city | Upper Demerara-Berbice | Guyana | 5.40 | -58.55 | 830 | 0 |
| Essequabu | city | Upper Demerara-Berbice | Guyana | 5.40 | -58.55 | 830 | 0 |
| Eupukari | city | Upper Takutu-Upper Essequibo | Guyana | 3.67 | -59.35 | 305 | 0 |
| Eurowa | city | Pomeroon-Supenaam | Guyana | 7.39 | -58.60 | 29 | 894 |
| Experience | city | Essequibo Islands-West Demerara | Guyana | 6.40 | -58.30 | 42 | 298 |