| Name | What | Region | Country | Lat | Long | Elev Ft. | Pop Est |
|---|
| Sabana de Ciego Banao | city | Provincia de Sancti Spiritus | Cuba | 21.5416667 | -79.5805556 | 0 | 8 |
| Sabanas de Caimiabo | city | Provincia de Sancti Spiritus | Cuba | 21.7 | -79.3166667 | 49 | 2213 |
| Sabanilla | city | Provincia de Sancti Spiritus | Cuba | 21.8166667 | -79.9166667 | 318 | 9676 |
| Salida | city | Provincia de Sancti Spiritus | Cuba | 21.9847222 | -79.1980556 | 242 | 7726 |
| Salina | city | Provincia de Sancti Spiritus | Cuba | 22.6333333 | -79.15 | 6 | 1136 |
| Salsipuede | city | Provincia de Sancti Spiritus | Cuba | 22.1166667 | -79.3833333 | 219 | 13236 |
| Salsipuedes | city | Provincia de Sancti Spiritus | Cuba | 22.1166667 | -79.3833333 | 219 | 13236 |
| Saltadero | city | Provincia de Sancti Spiritus | Cuba | 22.1333333 | -79.4333333 | 226 | 14098 |
| Saltadero de Neiva | city | Provincia de Sancti Spiritus | Cuba | 22.1333333 | -79.4333333 | 226 | 14098 |
| San Agustin | city | Provincia de Sancti Spiritus | Cuba | 21.9333333 | -79.4166667 | 249 | 15759 |
| San Agustin | city | Provincia de Sancti Spiritus | Cuba | 22.2894444 | -79.1416667 | 49 | 5506 |
| San Agustín | city | Provincia de Sancti Spiritus | Cuba | 21.9333333 | -79.4166667 | 249 | 15759 |
| San Agustín | city | Provincia de Sancti Spiritus | Cuba | 22.2894444 | -79.1416667 | 49 | 5506 |
| San Andres | city | Provincia de Sancti Spiritus | Cuba | 21.7666667 | -79.3833333 | 36 | 8988 |
| San Andrés | city | Provincia de Sancti Spiritus | Cuba | 21.7666667 | -79.3833333 | 36 | 8988 |
| San Carlos | city | Provincia de Sancti Spiritus | Cuba | 21.75 | -79.3833333 | 101 | 4654 |
| San Carlos del Quemado | city | Provincia de Sancti Spiritus | Cuba | 21.85 | -79.7666667 | 308 | 9743 |
| San Cristobal | city | Provincia de Sancti Spiritus | Cuba | 22.3047222 | -79.1997222 | 95 | 5503 |
| San Cristóbal | city | Provincia de Sancti Spiritus | Cuba | 22.3047222 | -79.1997222 | 95 | 5503 |
| San Fernando | city | Provincia de Sancti Spiritus | Cuba | 21.6630556 | -79.4505556 | 36 | 2210 |
| San Galillo | city | Provincia de Sancti Spiritus | Cuba | 22.05 | -79.05 | 725 | 6657 |
| San Geronimo | city | Provincia de Sancti Spiritus | Cuba | 22.05 | -79.0333333 | 705 | 7117 |
| San Isidro | city | Provincia de Sancti Spiritus | Cuba | 21.9 | -79.4333333 | 167 | 16094 |
| San Isidro | city | Provincia de Sancti Spiritus | Cuba | 22.1730556 | -79.2077778 | 669 | 5783 |
| San Jeronimo | city | Provincia de Sancti Spiritus | Cuba | 22.05 | -79.0333333 | 705 | 7117 |
| San Jerónimo | city | Provincia de Sancti Spiritus | Cuba | 22.05 | -79.0333333 | 705 | 7117 |
| San Jose | city | Provincia de Sancti Spiritus | Cuba | 21.9333333 | -79.4 | 170 | 15495 |
| San Jose | city | Provincia de Sancti Spiritus | Cuba | 22.2516667 | -79.2427778 | 780 | 5506 |
| San Jose | city | Provincia de Sancti Spiritus | Cuba | 22.15 | -79.0166667 | 390 | 6830 |
| San Jose de Las Canas | city | Provincia de Sancti Spiritus | Cuba | 21.7833333 | -79.8833333 | 78 | 7944 |
| San Jose de las Nuevas | city | Provincia de Sancti Spiritus | Cuba | 22.1775 | -79.2205556 | 656 | 6121 |
| San Jose del Lago | city | Provincia de Sancti Spiritus | Cuba | 22.2286111 | -79.0716667 | 308 | 5590 |
| San José | city | Provincia de Sancti Spiritus | Cuba | 21.9333333 | -79.4 | 170 | 15495 |
| San José | city | Provincia de Sancti Spiritus | Cuba | 22.2516667 | -79.2427778 | 780 | 5506 |
| San José | city | Provincia de Sancti Spiritus | Cuba | 22.15 | -79.0166667 | 390 | 6830 |
| San José de Las Cañas | city | Provincia de Sancti Spiritus | Cuba | 21.7833333 | -79.8833333 | 78 | 7944 |
| San José de las Nuevas | city | Provincia de Sancti Spiritus | Cuba | 22.1775 | -79.2205556 | 656 | 6121 |
| San José del Lago | city | Provincia de Sancti Spiritus | Cuba | 22.2286111 | -79.0716667 | 308 | 5590 |
| San Miguel | city | Provincia de Sancti Spiritus | Cuba | 22.0166667 | -79.2 | 305 | 8257 |
| San Nicolas | city | Provincia de Sancti Spiritus | Cuba | 22.1766667 | -79.2016667 | 679 | 5783 |
| San Nicolás | city | Provincia de Sancti Spiritus | Cuba | 22.1766667 | -79.2016667 | 679 | 5783 |
| San Pablo | city | Provincia de Sancti Spiritus | Cuba | 22.2313889 | -79.2025 | 905 | 5507 |
| San Pedro | city | Provincia de Sancti Spiritus | Cuba | 21.7508333 | -79.7663889 | 95 | 9529 |
| San Pedro | city | Provincia de Sancti Spiritus | Cuba | 22.2538889 | -79.0769444 | 134 | 5513 |
| San Rafael | city | Provincia de Sancti Spiritus | Cuba | 22.0333333 | -79.3833333 | 183 | 12780 |
| San Rafael | city | Provincia de Sancti Spiritus | Cuba | 22.1333333 | -79.0333333 | 488 | 6830 |
| Sancti Spiritus | city | Provincia de Sancti Spiritus | Cuba | 21.9297222 | -79.4425 | 170 | 15759 |
| Sancti Spíritus | city | Provincia de Sancti Spiritus | Cuba | 21.9297222 | -79.4425 | 170 | 15759 |
| Santa Ana | city | Provincia de Sancti Spiritus | Cuba | 22.013889 | -79.1761111 | 275 | 8257 |
| Santa Cruz | city | Provincia de Sancti Spiritus | Cuba | 22.0105556 | -79.4891667 | 200 | 14211 |
| Santa Cruz | city | Provincia de Sancti Spiritus | Cuba | 22.35 | -79.3166667 | 88 | 5120 |
| Santa Fidela | city | Provincia de Sancti Spiritus | Cuba | 21.9044444 | -79.0188889 | 318 | 7125 |
| Santa Gertrudis | city | Provincia de Sancti Spiritus | Cuba | 21.8302778 | -79.2416667 | 177 | 6595 |
| Santa Lucia | city | Provincia de Sancti Spiritus | Cuba | 22.0530556 | -79.5758333 | 400 | 14123 |
| Santa Lucía | city | Provincia de Sancti Spiritus | Cuba | 22.0530556 | -79.5758333 | 400 | 14123 |
| Santa Rosa | city | Provincia de Sancti Spiritus | Cuba | 21.8333333 | -79.9833333 | 95 | 9492 |
| Santa Rosalia de Ciego Caballo | city | Provincia de Sancti Spiritus | Cuba | 21.8536111 | -79.2225 | 177 | 6819 |
| Santa Rosalía de Ciego Caballo | city | Provincia de Sancti Spiritus | Cuba | 21.8536111 | -79.2225 | 177 | 6819 |
| Santa Teresa | city | Provincia de Sancti Spiritus | Cuba | 22.2333333 | -79.2666667 | 882 | 5507 |
| Santa Teresa | city | Provincia de Sancti Spiritus | Cuba | 22.0347222 | -78.9880556 | 554 | 7277 |
| Santo Domingo | city | Provincia de Sancti Spiritus | Cuba | 22.1333333 | -79.4666667 | 301 | 14194 |
| Santo Tomas | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.1333333 | 380 | 6770 |
| Santo Tomas de Lajita | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.1333333 | 380 | 6770 |
| Santo Tomás | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.1333333 | 380 | 6770 |
| Santo Tomás de Lajita | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.1333333 | 380 | 6770 |
| Seibabo | city | Provincia de Sancti Spiritus | Cuba | 22.3722222 | -79.3369444 | 32 | 5870 |
| Siete de Noviembre | city | Provincia de Sancti Spiritus | Cuba | 21.6622222 | -79.4708333 | 36 | 3261 |
| Sigoany | city | Provincia de Sancti Spiritus | Cuba | 21.9980556 | -79.3019444 | 200 | 13116 |
| Siguaguaco | city | Provincia de Sancti Spiritus | Cuba | 21.7422222 | -79.1938889 | 91 | 4295 |
| Siguaney | city | Provincia de Sancti Spiritus | Cuba | 21.9980556 | -79.3019444 | 200 | 13116 |
| Silencio | city | Provincia de Sancti Spiritus | Cuba | 21.7663889 | -79.1352778 | 88 | 6212 |
| Silvestre Rodriguez | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.4833333 | 288 | 15810 |
| Silvestre Rodríguez | city | Provincia de Sancti Spiritus | Cuba | 21.95 | -79.4833333 | 288 | 15810 |
| Simon Bolivar | city | Provincia de Sancti Spiritus | Cuba | 22.3416667 | -79.2183333 | 36 | 4379 |
| Simón Bolívar | city | Provincia de Sancti Spiritus | Cuba | 22.3416667 | -79.2183333 | 36 | 4379 |
| Sipiabo | city | Provincia de Sancti Spiritus | Cuba | 22.0166667 | -79.6833333 | 498 | 9380 |
| Sitio Nuevo | city | Provincia de Sancti Spiritus | Cuba | 22.1736111 | -79.1594444 | 629 | 5536 |
| Subiaurri | city | Provincia de Sancti Spiritus | Cuba | 21.6011111 | -79.1413889 | 3 | 1982 |
| Subirana | city | Provincia de Sancti Spiritus | Cuba | 21.6011111 | -79.1413889 | 3 | 1982 |
| Sucesores Guillermo Marin | city | Provincia de Sancti Spiritus | Cuba | 21.9833333 | -79.5333333 | 456 | 14977 |
| Sucesores Guillermo Marín | city | Provincia de Sancti Spiritus | Cuba | 21.9833333 | -79.5333333 | 456 | 14977 |
| Sucesores de Catalina Gallo | city | Provincia de Sancti Spiritus | Cuba | 21.9141667 | -79.1316667 | 285 | 6787 |